SCHEMBL23857795

SCHEMBL23857795

NCc1nc2c(C(N)=O)cccc2s1

nearest known ligand 0.47

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
UBE2T Q9NPD8 1/20 0.47
ASIC3 Q9UHC3 1/20 0.47
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
PARP1 P09874 17/20 0.45
PARP2 Q9UGN5 2/20 0.41
PARP3 Q9Y6F1 2/20 0.41
MEN1 O00255 1/20 0.38
ALDH1A1 P00352 1/20 0.38
HPGD P15428 1/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8583785 0.79 PARP1 (0.49) PARP1PARP2PARP3
SCHEMBL4470820 0.79 PDPK1 (0.59) PARP1PARP2PARP3ALDH1A1
SCHEMBL30874474 0.78 PARP1 (0.47) PARP1PARP2PARP3
SCHEMBL23874527 0.75 AURKA (0.43) NPC1RAB9APARP1PARP2PARP3
SCHEMBL17646416 0.74 PARP1 (0.37) NPC1RAB9APARP1PARP2PARP3
SCHEMBL23478496 0.73 LMNA (0.61) UBE2TASIC3NPC1RAB9AMEN1
SCHEMBL23874471 0.73 ASIC3 (0.53) UBE2TASIC3MEN1ALDH1A1HPGD
SCHEMBL21954228 0.73 SMN1; SMN2 (0.61) UBE2TASIC3NPC1RAB9AMEN1
SCHEMBL5973543 0.73 ALDH1A1 (0.61) UBE2TASIC3MEN1ALDH1A1HPGD
SCHEMBL29049097 0.72 NPC1 (0.44) NPC1RAB9APARP1MEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12247013-B2 Indane derivatives for use in the treatment of bacterial infection ANTABIO SAS (FR) 2025-03-11 US disclosed
CN-113166084-B Indane derivatives for the treatment of bacterial infections 安塔比奥公司 2024-06-04 CN disclosed
US-20240016941-A1 COMBINATION THERAPY ANTABIO SAS (FR) 2024-01-18 US disclosed
US-20240016941-A1 COMBINATION THERAPY ANTABIO SAS (FR) 2024-01-18 US disclosed
US-20240016941-A1 COMBINATION THERAPY ANTABIO SAS (FR) 2024-01-18 US disclosed
EP-4125883-A1 COMBINATION THERAPY Antabio SAS (FR) 2023-02-08 EP disclosed
US-20220112169-A1 INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION ANTABIO SAS (FR) 2022-04-14 US disclosed
WO-2021191240-A1 COMBINATION THERAPY ANTABIO SAS (FR) 2021-09-30 WO disclosed
WO-2021191240-A1 COMBINATION THERAPY ANTABIO SAS (FR) 2021-09-30 WO disclosed
CN-113166084-A Indane derivatives for the treatment of bacterial infections 安塔比奥公司 2021-07-23 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220112169-A1 INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION ARG1, ELANE, INSR UBE2T 1024/4885ASIC3 1279/4885NPC1 782/4885
US-20240016941-A1 COMBINATION THERAPY CFTR, ABCB11, SLC26A4 UBE2T 2566/4885ASIC3 420/4885NPC1 81/4885
US-12247013-B2 Indane derivatives for use in the treatment of bacterial infection ELANE, ARG1, INSRR UBE2T 956/4885ASIC3 1267/4885NPC1 679/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.