Sugi Predict

Sugi Predict / Compounds / SCHEMBL2390895

SCHEMBL2390895

SCHEMBL2390895

C1CC(c2nn[nH]n2)CN1

nearest known ligand 0.44

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ GRIK1 P39086 1/20 0.40
▸ GRIA1 P42261 1/20 0.40
▸ GRIA2 P42262 1/20 0.40
▸ GRIA3 P42263 1/20 0.40
▸ GRIA4 P48058 1/20 0.40
▸ GRIK2 Q13002 1/20 0.40
▸ GRIK3 Q13003 1/20 0.40
▸ GRIK4 Q16099 1/20 0.40
▸ GRIK5 Q16478 1/20 0.40
▸ HTR3A P46098 1/20 0.36
▸ HCAR3 P49019 1/20 0.32
▸ HCAR2 Q8TDS4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2390893 1.00 GRIK1 (0.40) GRIK1GRIA1GRIA2GRIA3GRIA4
SCHEMBL2392326 1.00 GRIK1 (0.40) GRIK1GRIA1GRIA2GRIA3GRIA4
Hydrochloric Acid SCHEMBL28987740 0.98 GRIK1 (0.39) GRIK1GRIA1GRIA2GRIA3GRIA4
SCHEMBL2390625 0.89 GRIK1 (0.38) GRIK1GRIA1GRIA2GRIA3GRIA4
SCHEMBL2390618 0.89 GRIK1 (0.38) GRIK1GRIA1GRIA2GRIA3GRIA4
SCHEMBL2392054 0.89 GRIK1 (0.38) GRIK1GRIA1GRIA2GRIA3GRIA4
SCHEMBL15549912 0.88 GRIK1 (0.39) GRIK1GRIA1GRIA2GRIA3GRIA4
Hydrochloric Acid SCHEMBL25343841 0.86 GRIK1 (0.38) GRIK1GRIA1GRIA2GRIA3GRIA4
SCHEMBL12269382 0.83 — —
Hydrochloric Acid SCHEMBL1602059 0.81 GRIK1 (0.40) GRIK1GRIA1GRIA2GRIA3GRIA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11873304-B2 Fused pyrimidine derivatives as A2A/A2B inhibitors INCYTE CORPORATION (US) 2024-01-16 — — US disclosed
US-11873291-B2 Quinoline cGAS antagonist compounds IMMUNESENSOR THERAPEUTICS, INC. (US) 2024-01-16 — — US disclosed
US-11168089-B2 Fused pyrimidine derivatives as A2A / A2B inhibitors INCYTE CORPORATION (US) 2021-11-09 — — US disclosed
EP-3810610-A1 FUSED PYRIMIDINE DERIVATIVES AS A2A / A2B INHIBITORS Incyte Corporation (US) 2021-04-28 — — EP disclosed
EP-2358202-B1 BENZIMIDAZOLE AND AZA-BENZIMIDAZOLE CARBOXAMIDES MERCK SHARP & DOHME (US) 2016-06-15 — — EP disclosed
EP-2225238-B1 DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZOÝ1,2- ¨IMIDAZOLE-3- CARBOXYLIC ACID AMIDES BOEHRINGER INGELHEIM INT (DE) 2014-09-03 — — EP disclosed
EP-2375904-B1 BIARYL CARBOXAMIDES MERCK SHARP & DOHME (US) 2014-05-28 — — EP disclosed
CN-101889011-B Derivatives of 6,7-dihydro-5h-imidazo[1,2-a]imidazole-3- carboxylic acid amides BOEHRINGER INGELHEIM INT 2014-05-28 — — CN disclosed
US-8552205-B2 Derivatives of 6,7-dihydro-5H-imidazo[1,2-alpha]imidazole-3-carboxylic acid amides BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-10-08 — — US disclosed
US-8470819-B2 Benzimidazole and aza-benzimidazole carboxamides MERCK SHARP & DOHME CORP. (US) 2013-06-25 — — US disclosed
US-8367679-B2 Biaryl carboxamides MERCK SHARP & DOHME CORP. (US) 2013-02-05 — — US disclosed
US-20110230498-A1 BIARYL CARBOXAMIDES MERCK SHARP & DOHME CORP. 2011-09-22 — — US disclosed
US-20110230498-A1 BIARYL CARBOXAMIDES MERCK SHARP & DOHME CORP. 2011-09-22 — — US disclosed
US-20110224188-A1 DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-alpha]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-09-15 — — US disclosed
US-20110207750-A1 BENZIMIDAZOLE AND AZA-BENZIMIDAZOLE CARBOXAMIDES MERCK SHARP & DOHME LLC 2011-08-25 — — US disclosed
US-20110207750-A1 BENZIMIDAZOLE AND AZA-BENZIMIDAZOLE CARBOXAMIDES MERCK SHARP & DOHME LLC 2011-08-25 — — US disclosed
EP-2225238-A1 DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZOÝ1,2- ¨IMIDAZOLE-3- CARBOXYLIC ACID AMIDES Boehringer Ingelheim International GmbH (DE) 2010-09-08 — — EP disclosed
WO-2010077624-A1 BIARYL CARBOXAMIDES MERCK SHARP & DOHME CORP. (US) 2010-07-08 — — WO disclosed
WO-2010051245-A1 BENZIMIDAZOLE AND AZA-BENZIMIDAZOLE CARBOXAMIDES MERCK SHARP & DOHME CORP. (US) 2010-05-06 — — WO disclosed
WO-2009070485-A1 DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-α]IMIDAZOLE-3- CARBOXYLIC ACID AMIDES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-06-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110224188-A1 DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-alpha]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES HPGDS, COL14A1, ARG1 GRIK1 714/4885GRIA1 897/4885GRIA2 1369/4885
US-11873304-B2 Fused pyrimidine derivatives as A2A/A2B inhibitors ADORA2A, ADORA2B, ADORA1 GRIK1 700/4885GRIA1 412/4885GRIA2 184/4885
US-11873291-B2 Quinoline cGAS antagonist compounds CGAS, GLS2, GLS GRIK1 936/4885GRIA1 572/4885GRIA2 445/4885
US-20110230498-A1 BIARYL CARBOXAMIDES PAFAH1B3, PAFAH1B2, FAAH2 GRIK1 1461/4885GRIA1 1790/4885GRIA2 1624/4885
US-11168089-B2 Fused pyrimidine derivatives as A2A / A2B inhibitors ADORA2A, ADORA2B, ADORA1 GRIK1 700/4885GRIA1 412/4885GRIA2 184/4885
US-20110207750-A1 BENZIMIDAZOLE AND AZA-BENZIMIDAZOLE CARBOXAMIDES PAFAH1B3, PAFAH1B2, PAF1 GRIK1 2049/4885GRIA1 2715/4885GRIA2 3334/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.