Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.44 |
| ▸ | GABRP | O00591 | 3/20 | 0.44 |
| ▸ | GABRD | O14764 | 3/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.44 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.44 |
| ▸ | GABRE | P78334 | 3/20 | 0.44 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.44 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.44 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.44 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23927177 | 0.88 | LMNA (0.60) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL30202195 | 0.88 | LMNA (0.60) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL23927211 | 0.86 | CHRM1 (0.47) | LMNANOTUM | |
| SCHEMBL23927200 | 0.85 | LMNA (0.43) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL23927197 | 0.85 | LMNA (0.51) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL23927214 | 0.83 | LMNA (0.49) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL23881540 | 0.83 | GABRA1 (0.49) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL30133111 | 0.83 | GABRA1 (0.49) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL23881526 | 0.83 | LMNA (0.49) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL23927174 | 0.80 | GABRA1 (0.55) | LMNAGABRA1GABRA5GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260008781-A1 | NEW BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | HOFFMANN LA ROCHE (US) | 2026-01-08 | — | — | US | disclosed |
| EP-4408848-B1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 POSITIVE ALLOSTERIC MODULATORS | HOFFMANN LA ROCHE (CH) | 2025-11-05 | — | — | EP | disclosed |
| US-12365687-B2 | Benzodiazepine derivatives as GABA A gamma 1 PAM | HOFFMANN-LA ROCHE INC. (US) | 2025-07-22 | — | — | US | disclosed |
| EP-4408848-A1 | NEW BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. Hoffmann-La Roche AG (CH) | 2024-08-07 | — | — | EP | disclosed |
| EP-4405043-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. Hoffmann-La Roche AG (CH) | 2024-07-31 | — | — | EP | disclosed |
| CN-118019742-A | Novel benzodiazepine derivatives as GABA Aγ1 PAM | 豪夫迈·罗氏有限公司 | 2024-05-10 | — | — | CN | disclosed |
| EP-4139310-B1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | HOFFMANN LA ROCHE (CH) | 2024-03-27 | — | — | EP | disclosed |
| US-20230141603-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | HOFFMANN-LA ROCHE INC. (US) | 2023-05-11 | — | — | US | disclosed |
| US-20230136326-A1 | NEW BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA 1 PAM | HOFFMANN-LA ROCHE INC. (US) | 2023-05-04 | — | — | US | disclosed |
| US-20230136326-A1 | NEW BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA 1 PAM | HOFFMANN-LA ROCHE INC. (US) | 2023-05-04 | — | — | US | disclosed |
| WO-2023052312-A1 | NEW BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. HOFFMANN-LA ROCHE AG (CH) | 2023-04-06 | — | — | WO | disclosed |
| WO-2023046817-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. HOFFMANN-LA ROCHE AG (CH) | 2023-03-30 | — | — | WO | disclosed |
| EP-4139310-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. Hoffmann-La Roche AG (CH) | 2023-03-01 | — | — | EP | disclosed |
| WO-2021213952-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. HOFFMANN-LA ROCHE AG (CH) | 2021-10-28 | — | — | WO | disclosed |
| EP-3901155-A1 | NEW BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. Hoffmann-La Roche AG (CH) | 2021-10-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12365687-B2 | Benzodiazepine derivatives as GABA A gamma 1 PAM | GABRA1, GABRB1, GABRG1 | LMNA 2569/4885GABRA1 1/4885GABRA5 4/4885 |
| US-20230136326-A1 | NEW BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA 1 PAM | GABRA1, GABRB1, GABRA5 | LMNA 2641/4885GABRA1 1/4885GABRA5 3/4885 |
| US-20260008781-A1 | NEW BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | GABRA1, GABRA6, GABRB1 | LMNA 2020/4885GABRA1 1/4885GABRA5 7/4885 |
| US-20230141603-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | GABRA1, GABRB1, GABRB3 | LMNA 2279/4885GABRA1 1/4885GABRA5 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.