Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29755206 | 1.00 | KMT2A (0.55) | KMT2AMEN1SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL2084609 | 1.00 | KMT2A (0.55) | KMT2AMEN1SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL6218406 | 0.83 | ALDH1A1 (0.52) | KMT2AMEN1SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL4840329 | 0.83 | ALDH1A1 (0.52) | KMT2AMEN1SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL4840325 | 0.83 | ALDH1A1 (0.52) | KMT2AMEN1SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL13609700 | 0.80 | KDM4E (0.63) | KMT2AMEN1SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL15009569 | 0.79 | CES2 (0.67) | KMT2ASMN1; SMN2RAB9AALDH1A1KDM4E | |
| SCHEMBL3263280 | 0.79 | LMNA (0.59) | KMT2AMEN1SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL22559238 | 0.79 | LMNA (0.59) | KMT2AMEN1SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL3263278 | 0.79 | LMNA (0.59) | KMT2AMEN1SMN1; SMN2RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114072207-B | Bicyclic compounds | 维瓦斯治疗公司 | 2024-03-29 | — | — | CN | disclosed |
| US-20220298102-A1 | BICYCLIC COMPOUNDS | VIVACE THERAPEUTICS, INC. | 2022-09-22 | — | — | US | disclosed |
| US-11384049-B2 | — | — | 2022-07-12 | — | — | US | disclosed |
| US-20200347009-A1 | BICYCLIC COMPOUNDS | VIVACE THERAPEUTICS, INC. | 2020-11-05 | — | — | US | disclosed |
| WO-2020214734-A1 | BICYCLIC COMPOUNDS | VIVACE THERAPEUTICS, INC. (US) | 2020-10-22 | — | — | WO | disclosed |
| EP-2225238-B1 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZOÝ1,2- ¨IMIDAZOLE-3- CARBOXYLIC ACID AMIDES | BOEHRINGER INGELHEIM INT (DE) | 2014-09-03 | — | — | EP | disclosed |
| US-8552205-B2 | Derivatives of 6,7-dihydro-5H-imidazo[1,2-alpha]imidazole-3-carboxylic acid amides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-10-08 | — | — | US | disclosed |
| US-20110224188-A1 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-alpha]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-09-15 | — | — | US | disclosed |
| EP-2225238-A1 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZOÝ1,2- ¨IMIDAZOLE-3- CARBOXYLIC ACID AMIDES | Boehringer Ingelheim International GmbH (DE) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009070485-A1 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-α]IMIDAZOLE-3- CARBOXYLIC ACID AMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-06-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224188-A1 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-alpha]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES | HPGDS, COL14A1, ARG1 | KMT2A 2995/4885MEN1 4830/4885SMN1; SMN2 3828/4885 |
| US-20220298102-A1 | BICYCLIC COMPOUNDS | YAP1, TEAD2, TEAD3 | KMT2A 2248/4885MEN1 2739/4885SMN1; SMN2 3337/4885 |
| US-11384049-B2 | — | YAP1, HRAS, TFEB | KMT2A 2768/4885MEN1 2503/4885SMN1; SMN2 2955/4885 |
| US-20200347009-A1 | BICYCLIC COMPOUNDS | YAP1, TEAD2, TEAD3 | KMT2A 2248/4885MEN1 2739/4885SMN1; SMN2 3337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.