SCHEMBL2408989

SCHEMBL2408989

O=C1NC(=O)C2(CCC2)C(=O)N1

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.36
PGR P06401 1/20 0.33
KDM4E B2RXH2 1/20 0.32
OGT O15294 1/20 0.32
USP2 O75604 1/20 0.32
MAPT P10636 1/20 0.32
RECQL P46063 1/20 0.32
BLM P54132 1/20 0.32
MMP13 P45452 1/20 0.31
CRBN Q96SW2 1/20 0.30
PDE4A P27815 1/20 0.30
PDE4B Q07343 1/20 0.30
PDE4C Q08493 1/20 0.30
PDE4D Q08499 1/20 0.30
PDE3B Q13370 1/20 0.30
PDE3A Q14432 1/20 0.30
MMP2 P08253 1/20 0.30
MMP9 P14780 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13518063 0.94 LMNA (0.36) LMNAPGRKDM4EOGTUSP2
SCHEMBL4386817 0.92 LMNA (0.35) LMNAPGRKDM4EOGTUSP2
SCHEMBL4379931 0.92 LMNA (0.35) LMNAPGRKDM4EOGTUSP2
SCHEMBL4875346 0.88 LMNA (0.39) LMNAKDM4EOGTUSP2MAPT
SCHEMBL2640063 0.81 PGR (0.34) PGRCRBNPDE4APDE4BPDE4C
SCHEMBL677181 0.79 PGR (0.36) PGRKDM4ECRBNPDE4APDE4B
SCHEMBL11663614 0.74
SCHEMBL3516954 0.72 BACE1 (0.50) LMNAPGRMAPTPDE4APDE4B
SCHEMBL11407380 0.71 LMNA (0.30) LMNA
SCHEMBL9726922 0.69 GRIN1 (0.38) CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200147076-A1 PARENTERAL FORMULATIONS OF LIPOPHILIC PHARMACEUTICAL AGENTS AND METHODS FOR PREPARING AND USING THE SAME PLATFORM BRIGHTWORKS TWO, LTD. (US) 2020-05-14 US claimed
US-20180296556-A1 PARENTERAL FORMULATIONS OF LIPOPHILIC PHARMACEUTICAL AGENTS AND METHODS FOR PREPARING AND USING THE SAME PLATFORM BRIGHTWORKS TWO, LTD. (US) 2018-10-18 US claimed
US-20170172971-A1 PARENTERAL FORMULATIONS OF LIPOPHILIC PHARMACEUTICAL AGENTS AND METHODS FOR PREPARING AND USING THE SAME PLATFORM BRIGHTWORKS TWO, LTD. (US) 2017-06-22 US claimed
EP-2701684-A1 IMPROVED PARENTERAL FORMULATIONS OF LIPOPHILIC PHARMACEUTICAL AGENTS AND METHODS FOR PREPARING AND USING THE SAME Board Of Regents, The University Of Texas System (US) 2014-03-05 EP claimed
WO-2012148799-A1 IMPROVED PARENTERAL FORMULATIONS OF LIPOPHILIC PHARMACEUTICAL AGENTS AND METHODS FOR PREPARING AND USING THE SAME BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2012-11-01 WO claimed
US-20120277249-A1 PARENTERAL FORMULATIONS OF LIPOPHILIC PHARMACEUTICAL AGENTS AND METHODS FOR PREPARING AND USING THE SAME GREENJAY THERAPEUTICS, INC. 2012-11-01 US claimed
WO-2024151838-A1 CO-CRYSTALS WITH THIN-FILM FREEZE-DRYING PROCESS TO ENHANCE DELIVERY BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-07-18 WO disclosed
EP-4400491-A1 NOVEL LIPIDS USED FOR NUCLEIC ACID DELIVERY AND LIPID NANOPARTICLE COMPOSITION Themedium Therapeutics Co., Ltd (CN) 2024-07-17 EP disclosed
US-20240216515-A1 COMPOSITIONS AND METHODS FOR TARGETED DELIVERY TO CELLS THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM 2024-07-04 US disclosed
EP-4393511-A1 LIPID COMPOUND AND USE THEREOF Themedium Therapeutics Co., Ltd. (CN) 2024-07-03 EP disclosed
EP-4393484-A1 COMPOSITION FOR ORGAN-SPECIFIC DELIVERY OF NUCLEIC ACID Themedium Therapeutics Co., Ltd. (CN) 2024-07-03 EP disclosed
US-20240207178-A1 COMPOSITIONS AND METHODS FOR TARGETED DELIVERY TO CELLS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2024-06-27 US disclosed
US-20240197641-A1 COMPOSITIONS AND METHODS FOR TARGETED SYSTEMIC DELIVERY TO CELLS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2024-06-20 US disclosed
EP-2538784-A1 NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL ANTI-DIABETIC AGENTS Merck Sharp & Dohme Corp. (US) 2013-01-02 EP disclosed
US-20120309736-A1 NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL ANTI-DIABETIC AGENTS MERCK SHARP & DONME CORP 2012-12-06 US disclosed
US-20120277249-A1 PARENTERAL FORMULATIONS OF LIPOPHILIC PHARMACEUTICAL AGENTS AND METHODS FOR PREPARING AND USING THE SAME GREENJAY THERAPEUTICS, INC. 2012-11-01 US disclosed
WO-2011106273-A1 NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL ANTI-DIABETIC AGENTS MERCK SHARP & DOHME CORP. (US) 2011-09-01 WO disclosed
EP-2120871-A1 LINKER-BASED LECITHIN MICROEMULSION DELIVERY VEHICLES Acosta-Zara, Edgar, Joel (CA) 2009-11-25 EP disclosed
WO-2008070961-A1 LINKER-BASED LECITHIN MICROEMULSION DELIVERY VEHICLES ACOSTA-ZARA EDGAR JOEL (CA) 2008-06-19 WO disclosed
US-20080139392-A1 Linker-Based Lecithin Microemulsion Delivery Vehicles ACOSTA-ZARA EDGAR JOEL 2008-06-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120309736-A1 NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL ANTI-DIABETIC AGENTS PRKAG2, PRKAG1, PRKAB2 LMNA 2921/4885PGR 4674/4885KDM4E 2186/4885
US-20240207178-A1 COMPOSITIONS AND METHODS FOR TARGETED DELIVERY TO CELLS CHMP4B, LIPA, NPC1L1 LMNA 350/4885PGR 1690/4885KDM4E 4859/4885
US-20240216515-A1 COMPOSITIONS AND METHODS FOR TARGETED DELIVERY TO CELLS PNLIP, LIPA, PHOSPHO1 LMNA 164/4885PGR 2381/4885KDM4E 4050/4885
US-20240197641-A1 COMPOSITIONS AND METHODS FOR TARGETED SYSTEMIC DELIVERY TO CELLS SGMS2, SGMS1, LIPC LMNA 519/4885PGR 2178/4885KDM4E 4847/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.