Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | THRA | P10827 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27268590 | 0.88 | GABRP (0.43) | SMN1; SMN2NPC1RAB9APOLBHRH3 | |
| SCHEMBL5322016 | 0.86 | ROCK2 (0.36) | SMN1; SMN2NPC1RAB9AADRB2ADRB1 | |
| SCHEMBL27579802 | 0.86 | SMN1; SMN2 (0.40) | SMN1; SMN2HTTHRH3TP53KMT2A | |
| SCHEMBL27505139 | 0.82 | CHRNB2 (0.38) | — | |
| Cyclopropane Carboxylic Acid SCHEMBL2417778 | 0.78 | LMNA (0.41) | SMN1; SMN2NPC1RAB9APOLBKMT2A | |
| SCHEMBL8797375 | 0.78 | GAA (0.58) | HTTTHRBKMT2ATDP1ALDH1A1 | |
| SCHEMBL27356201 | 0.78 | SLC6A1 (0.50) | SMN1; SMN2KMT2AMAPTATM | |
| SCHEMBL12321171 | 0.76 | THRA (0.33) | HTTPOLBTHRATHRB | |
| SCHEMBL18520265 | 0.76 | NPC1 (0.40) | NPC1RAB9AADRB2ADRB1ADRB3 | |
| SCHEMBL6256278 | 0.75 | HTT (0.31) | SMN1; SMN2HTTKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2542555-B1 | PROCESS FOR PRODUCING PYRIPYROPENE DERIVATIVES | MEIJI SEIKA PHARMA CO LTD (JP) | 2016-09-21 | — | — | EP | disclosed |
| CN-102947312-B | Process for producing pyripyropene derivatives | MEIJI SEIKA KAISHA | 2015-05-27 | — | — | CN | disclosed |
| US-8853414-B2 | Process for producing pyripyropene derivatives | MEIJI SEIKA PHARMA CO., LTD. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-8853414-B2 | Process for producing pyripyropene derivatives | MEIJI SEIKA PHARMA CO., LTD. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-8853414-B2 | Process for producing pyripyropene derivatives | MEIJI SEIKA PHARMA CO., LTD. (JP) | 2014-10-07 | — | — | US | disclosed |
| US-20130060042-A1 | PROCESS FOR PRODUCING PYRIPYROPENE DERIVATIVES | MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) | 2013-03-07 | — | — | US | disclosed |
| US-20130060042-A1 | PROCESS FOR PRODUCING PYRIPYROPENE DERIVATIVES | MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) | 2013-03-07 | — | — | US | disclosed |
| CN-102947312-A | Process for producing pyripyropene derivatives | MEIJI SEIKA KAISHA | 2013-02-27 | — | — | CN | disclosed |
| EP-2542555-A1 | PROCESS FOR PRODUCING PYRIPYROPENE DERIVATIVES | Meiji Seika Pharma Co., Ltd. (JP) | 2013-01-09 | — | — | EP | disclosed |
| WO-2011108155-A1 | PROCESS FOR PRODUCING PYRIPYROPENE DERIVATIVES | MEIJI SEIKA KAISHA, LTD. (JP) | 2011-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130060042-A1 | PROCESS FOR PRODUCING PYRIPYROPENE DERIVATIVES | ACOX1, DHPS, CYP11B1 | SMN1; SMN2 3631/4885NPC1 3312/4885RAB9A 2673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.