Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | NR1D1 | P20393 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24144070 | 0.90 | HTR6 (0.54) | HTR6NR1D1HRH1EGFRKDR | |
| SCHEMBL24144290 | 0.87 | HTR6 (0.41) | HTR6NR1D1HRH1EGFRKDR | |
| SCHEMBL24144502 | 0.87 | CYP19A1 (0.47) | LMNAALDH1A1HTR6MKNK1MKNK2 | |
| SCHEMBL24144383 | 0.87 | CYP19A1 (0.49) | HTR6NR1D1TAAR1HRH1EGFR | |
| SCHEMBL24143555 | 0.85 | ROCK2 (0.46) | HTR6MAOBNR1D1TAAR1KMT2A | |
| SCHEMBL24144381 | 0.85 | ICMT (0.50) | HTR6MKNK1MKNK2MAOBNR1D1 | |
| SCHEMBL24143551 | 0.85 | NR1D1 (0.41) | HTR6MKNK1MKNK2NR1D1HRH1 | |
| SCHEMBL24143548 | 0.84 | NFATC1 (0.50) | LMNAALDH1A1HTR6MAOBNR1D1 | |
| SCHEMBL13621791 | 0.81 | ALDH1A1 (0.66) | LMNAALDH1A1HTR6SMN1; SMN2TAAR1 | |
| SCHEMBL2085631 | 0.81 | YES1 (0.46) | LMNAALDH1A1HTR6SMN1; SMN2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021263278-A1 | REV-ERB AGONISTS FOR THE TREATMENT OF TH17-MEDIATED INFLAMMATORY DISORDERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-12-30 | — | — | WO | disclosed |