Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | PRKX | P51817 | 1/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | NR1D1 | P20393 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24144070 | 0.85 | HTR6 (0.54) | EGFRIGF1RFLT4KDRNR1D1 | |
| SCHEMBL24144383 | 0.85 | CYP19A1 (0.49) | EGFRIGF1RFLT4KDRTAAR1 | |
| SCHEMBL24144290 | 0.85 | HTR6 (0.41) | ROCK2ROCK1EGFRIGF1RFLT4 | |
| SCHEMBL24144386 | 0.85 | LMNA (0.45) | MAOBEGFRIGF1RFLT4KDR | |
| SCHEMBL24144502 | 0.85 | CYP19A1 (0.47) | ROCK2ROCK1EGFRIGF1RFLT4 | |
| SCHEMBL24143220 | 0.82 | NR1D1 (0.67) | NR1D1 | |
| SCHEMBL24143551 | 0.82 | NR1D1 (0.41) | EGFRIGF1RFLT4KDRNR1D1 | |
| SCHEMBL24144381 | 0.82 | ICMT (0.50) | ROCK2ROCK1MAOBEGFRIGF1R | |
| SCHEMBL24143548 | 0.79 | NFATC1 (0.50) | MAOBEGFRIGF1RFLT4KDR | |
| SCHEMBL24143743 | 0.78 | NR1D1 (0.50) | ROCK2ROCK1PRKACAGSK3ANR1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021263278-A1 | REV-ERB AGONISTS FOR THE TREATMENT OF TH17-MEDIATED INFLAMMATORY DISORDERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-12-30 | — | — | WO | disclosed |