Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 11/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24252414 | 0.90 | GSK3B (0.38) | GSK3BCYP2D6CYP1A2CSNK1A1GSK3A | |
| SCHEMBL24252407 | 0.88 | GSK3B (0.40) | GSK3BCYP2D6CYP1A2CSNK1A1GSK3A | |
| SCHEMBL24252219 | 0.80 | PRKDC (0.33) | GSK3BCYP1A2MAPT | |
| SCHEMBL24252229 | 0.77 | LRRK2 (0.35) | GSK3BLRRK2 | |
| SCHEMBL24252410 | 0.73 | CCNT1 (0.33) | GSK3BMAPK11MAPK14CYP2D6 | |
| SCHEMBL24252409 | 0.72 | CCNT1 (0.33) | GSK3B | |
| SCHEMBL24252411 | 0.69 | CYP2D6 (0.33) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL24252408 | 0.69 | GSK3B (0.33) | GSK3BCYP2D6 | |
| SCHEMBL24252378 | 0.68 | LMNA (0.35) | MAPT | |
| SCHEMBL24252377 | 0.67 | HRH3 (0.35) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022034203-A1 | PROCESS FOR THE PREPARATION OF PYRIDAZINONE DERIVATIVES | SYNGENTA CROP PROTECTION AG (CH) | 2022-02-17 | — | — | WO | disclosed |