SCHEMBL24252377

SCHEMBL24252377

O=C1C=C(c2ncccn2)C(N2CCCCC2)O1

nearest known ligand 0.35

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 3/20 0.35
LMNA P02545 1/20 0.34
MAPT P10636 1/20 0.34
KDM4E B2RXH2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24252378 0.98 LMNA (0.35) HRH3LMNAMAPT
SCHEMBL24252219 0.87 PRKDC (0.33) LMNAMAPTKDM4E
SCHEMBL24252407 0.79 GSK3B (0.40)
SCHEMBL24252414 0.77 GSK3B (0.38)
SCHEMBL24252370 0.76 ROCK2 (0.34)
SCHEMBL24252374 0.74 ROCK2 (0.32)
SCHEMBL24252390 0.70 HRH3 (0.35) HRH3
SCHEMBL24252214 0.70
SCHEMBL24252372 0.68 ALDH1A1 (0.33) MAPT
SCHEMBL24252371 0.65

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116113630-A Process for preparing pyridazinone derivatives 先正达农作物保护股份公司 2023-05-12 CN disclosed
WO-2022034203-A1 PROCESS FOR THE PREPARATION OF PYRIDAZINONE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2022-02-17 WO disclosed