Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | PDE9A | O76083 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24252374 | 0.90 | ROCK2 (0.32) | PDE9A | |
| SCHEMBL24252370 | 0.88 | ROCK2 (0.34) | — | |
| SCHEMBL24252413 | 0.77 | GSK3B (0.43) | LRRK2GSK3B | |
| SCHEMBL24252219 | 0.77 | PRKDC (0.33) | GSK3BPIM1 | |
| SCHEMBL24252215 | 0.73 | PRMT5 (0.32) | — | |
| SCHEMBL24252373 | 0.72 | HDAC4 (0.33) | — | |
| SCHEMBL24252217 | 0.69 | — | — | |
| SCHEMBL24252375 | 0.69 | CYP2C8 (0.31) | — | |
| SCHEMBL24252212 | 0.66 | CTDSP1 (0.33) | — | |
| SCHEMBL24252378 | 0.65 | LMNA (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022034203-A1 | PROCESS FOR THE PREPARATION OF PYRIDAZINONE DERIVATIVES | SYNGENTA CROP PROTECTION AG (CH) | 2022-02-17 | — | — | WO | disclosed |