Irisolone

Irisolone

SCHEMBL242540

COc1c2c(cc3occ(-c4ccc(O)cc4)c(=O)c13)OCO2

nearest known ligand 0.73

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
UGT1A1 P22309 1/20 0.73
UGT1A8 Q9HAW9 1/20 0.73
EGFR P00533 2/20 0.61
KDM4E B2RXH2 5/20 0.58
POLB P06746 2/20 0.58
ALDH2 P05091 1/20 0.58
SMN1; SMN2 Q16637 8/20 0.53
MAPT P10636 8/20 0.53
CYP3A4 P08684 7/20 0.53
ALDH1A1 P00352 6/20 0.53
TP53 P04637 6/20 0.53
HPGD P15428 5/20 0.53
LMNA P02545 4/20 0.53
HSD17B10 Q99714 4/20 0.53
MAPK1 P28482 3/20 0.53
NPC1 O15118 6/20 0.52
RAB9A P51151 6/20 0.52
MEN1 O00255 5/20 0.52
KMT2A Q03164 5/20 0.52
CYP2C9 P11712 4/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Irisolone SCHEMBL29928854 1.00 UGT1A1 (0.73) UGT1A1UGT1A8EGFRKDM4EPOLB
SCHEMBL12073700 0.85 UGT1A1 (1.00) UGT1A1UGT1A8EGFRKDM4EPOLB
SCHEMBL30471499 0.84 UGT1A1 (0.52) UGT1A1UGT1A8EGFRKDM4EPOLB
Irisflorentin SCHEMBL29285415 0.84 ALDH1A1 (0.53) UGT1A1UGT1A8EGFRKDM4EPOLB
SCHEMBL31475104 0.78 ALDH1A1 (0.52) UGT1A1UGT1A8KDM4ESMN1; SMN2MAPT
SCHEMBL29441847 0.78 UGT1A1 (0.71) UGT1A1UGT1A8EGFRKDM4EPOLB
SCHEMBL29696493 0.78 UGT1A1 (0.69) UGT1A1UGT1A8EGFRKDM4EPOLB
Tectorigenin SCHEMBL351641 0.76 EGFR (1.00) UGT1A1UGT1A8EGFRKDM4EPOLB
Tectorigenin SCHEMBL29353966 0.76 EGFR (1.00) UGT1A1UGT1A8EGFRKDM4EPOLB
SCHEMBL28274172 0.75 KDM4E (0.67) EGFRKDM4EPOLBALDH2SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240315965-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2024-09-26 US claimed
US-20230089351-A1 METHODS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES Natural Extraction Systems, LLC (US) 2023-03-23 US claimed
WO-2022182527-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2022-09-01 WO claimed
WO-2022182523-A1 COMPOSITIONS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES Natural Extraction Systems, LLC (US) 2022-09-01 WO claimed
WO-2021158573-A1 METHODS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES Natural Extraction Systems, LLC (US) 2021-08-12 WO claimed
WO-2021158575-A1 COMPOSITIONS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES Natural Extraction Systems, LLC (US) 2021-08-12 WO claimed
CN-1986556-A Blackberry lily isoflavone compound and its application in medical field UNIV PLA 2ND MILITARY MEDICAL (CN) 2007-06-27 CN claimed
US-20260048025-A1 COMPOSITIONS AND METHODS RELATED TO DISSOLVED OXIDES NATURAL EXTRACTION SYS LLC (US) 2026-02-19 US disclosed
US-12409152-B2 Compositions and methods related to dissolved oxides Natural Extraction Systems, LLC (US) 2025-09-09 US disclosed
US-12329303-B1 Collapsible storage apparatus for securing packages McNaboe, Brian J. (US) 2025-06-17 US disclosed
CN-117897137-B Cosmetic composition containing iris bulb-derived exosome as effective component 瑞士派尊产品公司 2025-05-23 CN disclosed
US-20250161394-A1 Compositions Comprising Kavalactones NATURAL EXTRACTION SYS LLC (US) 2025-05-22 US disclosed
US-20250127709-A1 COSMETIC COMPOSITION CONTAINING IRIS GERMANICA ROOT-DERIVED EXOSOMES AS AN ACTIVE INGREDIENT PP Produits Prestiges SA (CH) 2025-04-24 US disclosed
US-20020027140-A1 MEDICAL WASTE SEGREGATION APPARATUS WITH MOVEABLE FLOOR GEORGE SCOTT A (US) 2002-03-07 US disclosed
WO-2001087719-A1 MEDICAL WASTE SEGREGATION APPARATUS WITH MOVEABLE FLOOR GEORGE SCOTT A (US) 2001-11-22 WO disclosed
US-6209744-B1 Hinge-doored receptacle CALHOUN & HAASE PLLC 2001-04-03 US disclosed
US-6000938-A Automated door mechanism for heat treating furnace MELANOWICZ AREK (US) 1999-12-14 US disclosed
US-5968520-A PLANT EXTRACTS FROM ALDER AND MOUNTAIN ASH; HANGOVER REMEDY NAM JONG HYUN (KR) 1999-10-19 US disclosed
EP-0878199-A1 NATURAL TEAS FOR TAKING OFF THE EFFECTS OF DRINK AND PROCESS FOR THE PRODUCTION THEREOF Nam, Jong Hyun (KR) 1998-11-18 EP disclosed
US-5372271-A Pedal actuated waste disposal bin MILLER MICHAEL G (US) 1994-12-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230089351-A1 METHODS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES FABP2, FABP4, GUSB UGT1A1 1445/4885UGT1A8 1189/4885EGFR 2528/4885
US-12409152-B2 Compositions and methods related to dissolved oxides PRKG2, PRKG1, CIT UGT1A1 4272/4885UGT1A8 4229/4885EGFR 2451/4885
US-20260048025-A1 COMPOSITIONS AND METHODS RELATED TO DISSOLVED OXIDES SCO2, CNR2, CNR1 UGT1A1 821/4885UGT1A8 1247/4885EGFR 2528/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.