Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | SELL | P14151 | 1/20 | 0.48 |
| ▸ | SELP | P16109 | 1/20 | 0.48 |
| ▸ | SELE | P16581 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254523 | 0.88 | HPGD (0.59) | ALDH1A1LMNAPOLBRAB9AMAPT | |
| SCHEMBL14227348 | 0.79 | LMNA (0.67) | ALDH1A1LMNAPOLBRAB9AMAPT | |
| SCHEMBL24254495 | 0.77 | ALDH1A1 (1.00) | ALDH1A1LMNAPOLBRAB9AMAPT | |
| SCHEMBL29844215 | 0.77 | POLB (0.80) | ALDH1A1LMNAPOLBRAB9AMAPT | |
| SCHEMBL8440269 | 0.77 | POLB (0.80) | ALDH1A1LMNAPOLBRAB9AMAPT | |
| SCHEMBL24254545 | 0.77 | SELL (0.45) | LMNAPOLBMAPTHTTMEN1 | |
| SCHEMBL24254539 | 0.75 | MAPT (0.53) | ALDH1A1LMNAMAPTHTTMEN1 | |
| SCHEMBL24254575 | 0.74 | MAPT (0.53) | ALDH1A1LMNAPOLBMAPTHTT | |
| SCHEMBL24254578 | 0.72 | L3MBTL1 (0.57) | ALDH1A1LMNAPOLBMAPTHTT | |
| SCHEMBL24254579 | 0.71 | MEN1 (0.57) | ALDH1A1POLBHTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035804-A1 | SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |