Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ANXA2 | P07355 | 1/20 | 0.46 |
| ▸ | S100A10 | P60903 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254511 | 0.78 | ALDH1A1 (0.76) | MEN1KMT2AALDH1A1KDM4EPKM | |
| SCHEMBL24254523 | 0.73 | HPGD (0.59) | MEN1KMT2AALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL24254545 | 0.72 | SELL (0.45) | MEN1KMT2APKMPOLBSMN1; SMN2 | |
| SCHEMBL24254498 | 0.71 | ALDH1A1 (0.63) | MEN1KMT2AALDH1A1KDM4EALOX15 | |
| SCHEMBL24254575 | 0.70 | MAPT (0.53) | MEN1KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL6261397 | 0.69 | ALOX15 (0.74) | MEN1KMT2AALDH1A1KDM4EALOX15 | |
| SCHEMBL8288400 | 0.69 | LMNA (0.68) | MEN1KMT2AALDH1A1KDM4EALOX15 | |
| SCHEMBL9030697 | 0.68 | MEN1 (0.69) | MEN1KMT2AALDH1A1PKMPOLB | |
| SCHEMBL2964946 | 0.68 | RAD52 (0.63) | MEN1KMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL24254578 | 0.68 | L3MBTL1 (0.57) | MEN1KMT2AALDH1A1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035804-A1 | SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |