SCHEMBL2425702

SCHEMBL2425702

CO[Si](OC)(c1c(C)cc(C)cc1C)c1c(C)cc(C)cc1C

nearest known ligand 0.36

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 3/20 0.36
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
LMNA P02545 1/20 0.36
GAA P10253 1/20 0.36
MAPT P10636 1/20 0.36
ACHE P22303 1/20 0.33
NOS3 P29474 1/20 0.31
NOS1 P29475 1/20 0.31
NOS2 P35228 1/20 0.31
CYP1A2 P05177 1/20 0.30
CYP2A6 P11509 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3108980 0.79 ACHE (0.39) RAPGEF4KDM4EALDH1A1LMNAGAA
SCHEMBL3339303 0.73 NLRP3 (0.33) RAPGEF4KDM4EALDH1A1LMNAGAA
SCHEMBL17805213 0.72 KDM4E (0.31) RAPGEF4KDM4EALDH1A1LMNAGAA
SCHEMBL13027094 0.70 ACHE (0.52) KDM4EALDH1A1LMNAMAPTACHE
SCHEMBL13295957 0.69 RAPGEF4 (0.41) RAPGEF4KDM4EALDH1A1LMNAGAA
SCHEMBL13296036 0.69 RAPGEF4 (0.41) RAPGEF4KDM4EALDH1A1LMNAGAA
SCHEMBL1314789 0.67 RAPGEF4 (0.39) RAPGEF4KDM4EALDH1A1LMNAGAA
SCHEMBL4464617 0.67 RAPGEF4 (0.39) RAPGEF4KDM4EALDH1A1LMNAGAA
SCHEMBL297423 0.67 RAPGEF4 (0.39) RAPGEF4KDM4EALDH1A1LMNAGAA
SCHEMBL1686911 0.67 ALDH1A1 (0.44) RAPGEF4KDM4EALDH1A1LMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1782436-B1 METHOD FOR TREATING ELECTRICAL CABLE AT SUSTAINED ELEVATED PRESSURE NOVINIUM INC (US) 2017-05-31 EP disclosed
US-9170492-B2 Silicon-containing film-forming composition, silicon-containing film, and pattern forming method JSR CORPORATION (JP) 2015-10-27 US disclosed
US-9140985-B2 2015-09-22 US disclosed
US-8968458-B2 Composition for resist underlayer film and process for producing same JSR CORPORATION (JP) 2015-03-03 US disclosed
US-8808446-B2 Composition for resist underlayer film and process for producing same JSR CORPORATION (JP) 2014-08-19 US disclosed
EP-2121273-B1 ACID-CATALYZED DIELECTRIC ENHANCEMENT FLUID AND CABLE RESTORATION METHOD EMPLOYING SAME NOVINIUM INC (US) 2014-06-25 EP disclosed
US-8656586-B2 Method for treating electrical cable at sustained elevated pressure NOVINIUM, INC. (US) 2014-02-25 US disclosed
EP-1744866-B1 METHOD FOR SELECTING FORMULATIONS TO TREAT ELECTRICAL CABLES NOVINIUM INC (US) 2012-08-08 EP disclosed
US-8205326-B2 Method for treating electrical cable at sustained elevated pressure NOVINIUM, INC. (US) 2012-06-26 US disclosed
US-20120102729-A1 METHOD FOR TREATING ELECTRICAL CABLE AT SUSTAINED ELEVATED PRESSURE NOVINIUM, INC. (US) 2012-05-03 US disclosed
US-20090023855-A1 NOVEL CURABLE RESIN, PRODUCTION METHOD THEREOF, EPOXY RESIN COMPOSITION, AND ELECTRONIC DEVICE RESONAC CORPORATION (JP) 2009-01-22 US disclosed
US-20080249326-A1 High-Endurance Packing Material for Liquid Chromatography DAISO CO., LTD (JP) 2008-10-09 US disclosed
US-20080173467-A1 ACID-CATALYZED DIELECTRIC ENHANCEMENT FLUID AND CABLE RESTORATION METHOD EMPLOYING SAME NOVINIUM, INC. (US) 2008-07-24 US disclosed
EP-1855159-A1 COMPOSITION FOR UNDERLAYER FILM OF RESIST AND PROCESS FOR PRODUCING THE SAME JSR Corporation (JP) 2007-11-14 EP disclosed
US-20050192708-A1 Method for selecting formulations to treat electrical cables NOVINIUM, INC. (US) 2005-09-01 US disclosed
US-20050189130-A1 Method for treating electrical cable at sustained elevated pressure NOVINIUM, INC. (US) 2005-09-01 US disclosed
US-6433119-B1 COORDINATION CATALYST ON CATALYST SUPPORT BASELL POLIOLEFINE ITALIA S.P.A. (IT) 2002-08-13 US disclosed
US-6054406-A ZIEGLER-NATTA CATALYST FOR POLYMERIZING ALPHA-OLEFIN MONTELL NORTH AMERICA INC. (US) 2000-04-25 US disclosed
EP-0423786-B1 Polymetallic catalysts, method of preparing and polymers produced thereby MONTELL NORTH AMERICA INC (US) 1998-12-16 EP disclosed
EP-0423786-A2 Polymetallic catalysts, method of preparing and polymers produced thereby MONTELL NORTH AMERICA INC. (US) 1991-04-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080249326-A1 High-Endurance Packing Material for Liquid Chromatography CCL2, CCR2, CX3CR1 RAPGEF4 2346/4885KDM4E 647/4885ALDH1A1 257/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.