Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 12/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24316432 | 0.86 | ACACB (0.37) | GRM5PIK3CAMTOR | |
| SCHEMBL24316428 | 0.83 | ALKBH1 (0.39) | GRM5 | |
| SCHEMBL24316623 | 0.77 | P2RX3 (0.39) | GRM5P2RX3 | |
| SCHEMBL24316814 | 0.76 | CSF1R (0.47) | GRM5P2RX7PIK3CAMTORP2RX3 | |
| SCHEMBL24316565 | 0.76 | CSF1R (0.44) | GRM5PIK3CAMTOR | |
| SCHEMBL24316436 | 0.73 | KDM4E (0.37) | GRM5PIK3CAMTOR | |
| SCHEMBL24316434 | 0.72 | CSF1R (0.53) | GRM5PIK3CAMTOR | |
| SCHEMBL24316659 | 0.72 | ALKBH1 (0.40) | GRM5 | |
| SCHEMBL24316545 | 0.72 | CSF1R (0.43) | GRM5PIK3CAMTOR | |
| SCHEMBL24316624 | 0.71 | KDM4E (0.36) | GRM5PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022057895-A1 | HETEROAROMATIC COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2022-03-24 | — | — | WO | disclosed |
| US-9585884-B2 | Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 | AUSPEX PHARMACEUTICALS, INC. (US) | 2017-03-07 | — | — | US | disclosed |