Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | ACACA | Q13085 | 1/20 | 0.37 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24316428 | 0.91 | ALKBH1 (0.39) | ACACBACACAALKBH1GRM5ALDH1A1 | |
| SCHEMBL24316438 | 0.86 | GRM5 (0.43) | GRM5PIK3CAMTOR | |
| SCHEMBL24316659 | 0.79 | ALKBH1 (0.40) | ALKBH1GRM5ALDH1A1HPGDUSP2 | |
| SCHEMBL24316565 | 0.78 | CSF1R (0.44) | ALKBH1GRM5ALDH1A1HPGDPIK3CA | |
| SCHEMBL24316436 | 0.78 | KDM4E (0.37) | GRM5ALDH1A1PIK3CAMTORMCHR1 | |
| SCHEMBL24316623 | 0.78 | P2RX3 (0.39) | ALKBH1GRM5ALDH1A1MCHR1MAOB | |
| SCHEMBL24316545 | 0.76 | CSF1R (0.43) | ALKBH1GRM5ALDH1A1HPGDPIK3CA | |
| SCHEMBL24316624 | 0.75 | KDM4E (0.36) | GRM5ALDH1A1HPGDPIK3CAMTOR | |
| SCHEMBL24316434 | 0.75 | CSF1R (0.53) | ALKBH1GRM5ALDH1A1HPGDPIK3CA | |
| SCHEMBL24316522 | 0.72 | ALDH1A1 (0.48) | ALDH1A1HPGDPIK3CAMTORCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022057895-A1 | HETEROAROMATIC COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2022-03-24 | — | — | WO | disclosed |
| US-9585884-B2 | Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 | AUSPEX PHARMACEUTICALS, INC. (US) | 2017-03-07 | — | — | US | disclosed |