Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | IKZF2 | Q9UKS7 | 3/20 | 0.36 |
| ▸ | SDCBP | O00560 | 5/20 | 0.35 |
| ▸ | SDC2 | P34741 | 5/20 | 0.35 |
| ▸ | CCR2 | P41597 | 3/20 | 0.32 |
| ▸ | NPY2R | P49146 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24790789 | 0.80 | IKZF2 (0.35) | THRBIKZF2MAPT | |
| SCHEMBL25626791 | 0.77 | DRD2 (0.42) | THRBIKZF2SDCBPSDC2MAPT | |
| SCHEMBL24421543 | 0.77 | SDCBP (0.50) | THRBSDCBPSDC2MAPT | |
| SCHEMBL25615504 | 0.77 | NAMPT (0.41) | IKZF2 | |
| SCHEMBL24891481 | 0.76 | NAMPT (0.36) | THRBMAPT | |
| SCHEMBL25619160 | 0.74 | THRB (0.34) | THRBIKZF2SDCBPSDC2MAPT | |
| SCHEMBL27370457 | 0.74 | CNR1 (0.39) | MAPT | |
| SCHEMBL24421185 | 0.73 | ITGB3 (0.35) | THRBTP53 | |
| SCHEMBL23984162 | 0.73 | ITGB3 (0.39) | THRBMAPT | |
| SCHEMBL24891345 | 0.73 | THRB (0.34) | THRBSDCBPSDC2TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |