Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 5/20 | 0.48 |
| ▸ | NOS3 | P29474 | 4/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.38 |
| ▸ | HTR3B | O95264 | 4/20 | 0.38 |
| ▸ | HTR3A | P46098 | 4/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.37 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | NPFFR2 | Q9Y5X5 | 2/20 | 0.36 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3418772 | 0.78 | SIGMAR1 (0.50) | NOS1NOS3HTR3EHTR3BHTR3A | |
| Hydrochloric Acid SCHEMBL3242566 | 0.76 | NOS1 (0.50) | NOS1NOS3HTR3EHTR3BHTR3A | |
| SCHEMBL13655894 | 0.71 | HTR2A (0.33) | — | |
| SCHEMBL24456383 | 0.71 | HTR3E (0.72) | NOS1NOS3HTR3EHTR3BHTR3A | |
| SCHEMBL1116487 | 0.71 | ITGB3 (0.37) | NOS1NOS3HTR3EHTR3BHTR3A | |
| SCHEMBL4491422 | 0.71 | HTR3E (0.53) | NOS1NOS3HTR3EHTR3BHTR3A | |
| Hydrochloric Acid SCHEMBL2861960 | 0.69 | HTR3E (0.69) | NOS1NOS3HTR3EHTR3BHTR3A | |
| SCHEMBL13201480 | 0.69 | NPC1 (0.31) | — | |
| SCHEMBL23418137 | 0.67 | MPO (0.42) | NOS1NOS3SLC22A2SLC22A1SLC22A3 | |
| SCHEMBL16957960 | 0.67 | CES2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109492-A1 | PYRROLOPYRIDAZINE COMPOUNDS AS KINASE INHIBITORS | GOSSAMER BIOSERVICES, INC. (US) | 2022-05-27 | — | — | WO | disclosed |