Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 3/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29145555 | 0.98 | KCNN4 (0.44) | KCNN4PTPN1ALDH1A1TSHRMAPT | |
| SCHEMBL29095960 | 0.98 | KCNN4 (0.44) | KCNN4PTPN1ALDH1A1TSHRMAPT | |
| SCHEMBL11395704 | 0.84 | KCNN4 (0.47) | KCNN4PTPN1ALDH1A1TSHRMAPT | |
| SCHEMBL506922 | 0.81 | KCNN4 (0.64) | KCNN4PTPN1ALDH1A1TSHRMAPT | |
| SCHEMBL27568720 | 0.81 | KCNN4 (0.44) | KCNN4PTPN1ALDH1A1TSHRMAPT | |
| SCHEMBL8583194 | 0.79 | KCNN4 (0.42) | KCNN4PTPN1ALDH1A1TSHRMAPT | |
| SCHEMBL28049560 | 0.78 | CHRM3 (0.46) | KCNN4ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL28468609 | 0.78 | KCNN4 (0.41) | KCNN4PTPN1ALDH1A1TSHRMAPT | |
| SCHEMBL11395708 | 0.78 | KCNN4 (0.46) | KCNN4PTPN1ALDH1A1TSHRMAPT | |
| SCHEMBL17993799 | 0.78 | KCNN4 (0.46) | KCNN4PTPN1ALDH1A1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116730795-B | Synthesis method of trifluoro-phenylacetic acid intermediate 1,2, 4-trifluoro-benzene | 山东国邦药业有限公司 | 2023-10-27 | — | — | CN | claimed |
| CN-116730795-A | Synthesis method of trifluoro-phenylacetic acid intermediate 1,2, 4-trifluoro-benzene | 山东国邦药业有限公司 | 2023-09-12 | — | — | CN | claimed |
| WO-2010122578-A2 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND ITS INTERMEDIATES | MSN LABORATORIES LIMITED (IN) | 2010-10-28 | — | — | WO | claimed |
| EP-4151620-B1 | METHOD FOR PREPARING CHIRAL 4-ARYL-BETA-AMINO ACID DERIVATIVE | ZHEJIANG MED XINCHANG PHARM (CN) | 2026-04-08 | — | — | EP | disclosed |
| US-12534427-B2 | Method for preparing chiral 4-aryl-β-amino acid derivative | ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY (CN) | 2026-01-27 | — | — | US | disclosed |
| CN-117384026-A | Preparation method of phenylacetic acid compound | 台州臻挚生物科技有限公司 | 2024-01-12 | — | — | CN | disclosed |
| CN-116947638-A | Method for preparing sitagliptin intermediate by one-pot method | 淄博飞源化工有限公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-116730795-B | Synthesis method of trifluoro-phenylacetic acid intermediate 1,2, 4-trifluoro-benzene | 山东国邦药业有限公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-116730795-B | Synthesis method of trifluoro-phenylacetic acid intermediate 1,2, 4-trifluoro-benzene | 山东国邦药业有限公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-116730795-A | Synthesis method of trifluoro-phenylacetic acid intermediate 1,2, 4-trifluoro-benzene | 山东国邦药业有限公司 | 2023-09-12 | — | — | CN | disclosed |
| CN-116730795-A | Synthesis method of trifluoro-phenylacetic acid intermediate 1,2, 4-trifluoro-benzene | 山东国邦药业有限公司 | 2023-09-12 | — | — | CN | disclosed |
| US-20050026929-A1 | Novel phenyl derivatives as inducers of apoptosis | AXYS PHARMACEUTICALS, INC. (US) | 2005-02-03 | — | — | US | disclosed |
| WO-2004083212-A1 | PROCESS TO BETA-KETOAMIDE INTERMEDIATES TO DIPEPTIDYL PEPTIDASE INHIBITORS | MERCK & CO., INC. (US) | 2004-09-30 | — | — | WO | disclosed |
| US-20040077901-A1 | Process for the synthesis of trifluorophenylacetic acids | MERCK SHARP & DOHME LLC | 2004-04-22 | — | — | US | disclosed |
| US-20040077901-A1 | Process for the synthesis of trifluorophenylacetic acids | MERCK SHARP & DOHME LLC | 2004-04-22 | — | — | US | disclosed |
| US-20040077901-A1 | Process for the synthesis of trifluorophenylacetic acids | MERCK SHARP & DOHME LLC | 2004-04-22 | — | — | US | disclosed |
| US-20040068141-A1 | Process for the synthesis of trifluorophenylacetic acids | ARMSTRONG JOSEPH D (US) | 2004-04-08 | — | — | US | disclosed |
| US-20040068141-A1 | Process for the synthesis of trifluorophenylacetic acids | ARMSTRONG JOSEPH D (US) | 2004-04-08 | — | — | US | disclosed |
| WO-2003090680-A2 | NOVEL PHENYL DERIVATIVES AS INDUCERS OF APOPTOSIS | AXYS PHARMACEUTICALS, INC. (US) | 2003-11-06 | — | — | WO | disclosed |
| EP-0457243-A1 | Novel tricyclic compounds | SYNTEX (U.S.A.) INC. (US) | 1991-11-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12534427-B2 | Method for preparing chiral 4-aryl-β-amino acid derivative | OPRM1, SIGMAR1, GLRB | KCNN4 712/4885PTPN1 3461/4885ALDH1A1 2795/4885 |
| US-20050026929-A1 | Novel phenyl derivatives as inducers of apoptosis | BAX, BAD, CASP3 | KCNN4 4663/4885PTPN1 2929/4885ALDH1A1 1781/4885 |
| US-20040068141-A1 | Process for the synthesis of trifluorophenylacetic acids | PCCA, PAH, PFAS | KCNN4 2905/4885PTPN1 1118/4885ALDH1A1 611/4885 |
| US-20040077901-A1 | Process for the synthesis of trifluorophenylacetic acids | GRHPR, PFAS, PCCA | KCNN4 4553/4885PTPN1 2356/4885ALDH1A1 1082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.