Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 11/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.41 |
| ▸ | SMAD2 | Q15796 | 1/20 | 0.41 |
| ▸ | VRK1 | Q99986 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2462862 | 0.87 | DYRK1A (0.41) | DYRK1ARIPK1TGFBR1ALDH1A1HSD17B10 | |
| SCHEMBL31214345 | 0.84 | DYRK1A (0.72) | DYRK1ARIPK1TGFBR1APPKDM4E | |
| SCHEMBL2457178 | 0.75 | DYRK1A (0.54) | DYRK1ARIPK1TGFBR1APPKDM4E | |
| SCHEMBL6032917 | 0.75 | DYRK1A (0.62) | DYRK1ARIPK1TGFBR1APPKDM4E | |
| SCHEMBL27558183 | 0.74 | DYRK1A (0.60) | DYRK1ARIPK1TGFBR1APPKDM4E | |
| SCHEMBL16573976 | 0.74 | DYRK1A (0.60) | DYRK1ARIPK1TGFBR1APPKDM4E | |
| SCHEMBL6658073 | 0.74 | DYRK1A (0.60) | DYRK1ARIPK1TGFBR1APPKDM4E | |
| SCHEMBL22130152 | 0.74 | DYRK1A (0.70) | DYRK1ARIPK1TGFBR1APPKDM4E | |
| SCHEMBL2455990 | 0.73 | ALDH1A1 (0.36) | DYRK1ANPC1RAB9AALDH1A1CYP1A2 | |
| SCHEMBL17691820 | 0.72 | DYRK1A (0.63) | DYRK1ARIPK1TGFBR1APPKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110237633-A1 | SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2011-09-29 | — | — | US | disclosed |
| WO-2010068287-A2 | SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORP. (US) | 2010-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237633-A1 | SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | HGF, HDGF, MET | DYRK1A 4134/4885RIPK1 3658/4885TGFBR1 304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.