SCHEMBL246635

SCHEMBL246635

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4CC(OC(=O)Oc5ccccc5)CC[C@]4(C)[C@H]3CC[C@]12C

nearest known ligand 0.73

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
POLA1 P09884 1/20 0.73
CYP46A1 Q9Y6A2 2/20 0.69
OSBP P22059 3/20 0.65
USP2 O75604 2/20 0.65
RORC P51449 2/20 0.65
LMNA P02545 1/20 0.65
ABCB1 P08183 1/20 0.65
OSBP2 Q969R2 1/20 0.65
NPC1 O15118 1/20 0.59
CYP1A2 P05177 1/20 0.58
NR1H3 Q13133 3/20 0.58
NPC1L1 Q9UHC9 2/20 0.57
EPHA2 P29317 2/20 0.56
GBA1 P04062 2/20 0.56
UGCG Q16739 2/20 0.56
GBA2 Q9HCG7 2/20 0.56
GRIN1 Q05586 1/20 0.56
GRIN2A Q12879 1/20 0.56
PLA2G2A P14555 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL767548 1.00 POLA1 (0.73) POLA1CYP46A1OSBPUSP2RORC
SCHEMBL246636 1.00 POLA1 (0.73) POLA1CYP46A1OSBPUSP2RORC
SCHEMBL11563103 0.94 POLA1 (0.65) POLA1CYP46A1OSBPUSP2RORC
SCHEMBL11563100 0.94 POLA1 (0.65) POLA1CYP46A1OSBPUSP2RORC
SCHEMBL12290965 0.94 POLA1 (0.69) POLA1CYP46A1OSBPUSP2RORC
SCHEMBL137969 0.92 POLA1 (0.79) POLA1CYP46A1OSBPUSP2RORC
SCHEMBL6419070 0.92 POLA1 (0.79) POLA1CYP46A1OSBPUSP2RORC
SCHEMBL25352991 0.92 POLA1 (0.66) POLA1CYP46A1OSBPUSP2RORC
SCHEMBL8097151 0.92 POLA1 (0.66) POLA1CYP46A1OSBPUSP2RORC
SCHEMBL2565939 0.92 POLA1 (0.66) POLA1CYP46A1OSBPUSP2RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060115445-A1 Compositions for treating keratin materials comprising electrophilic monomers and liquid crystal agents L'OREAL S.A. (FR) 2006-06-01 US claimed
EP-1647259-A1 use for treatment of keratinic materials of compositions comprising electrophilic monomers and agents forming liquid crystals L'OREAL (FR) 2006-04-19 EP claimed
US-6328910-B1 FOR IN SITU FORMATION OF AN POLYMERIC CYANOACRYLATE FILM ON MAMMALIAN SKIN WHICH CAN BE USED TO MONITOR THE SURFACE SKIN TEMPERATURE OF MAMMAL MEDLOGIC GLOBAL CORPORATION 2001-12-11 US claimed
CN-105596233-B Anhydrous fluid filter composition comprising an oily phase, a specific triazine filter and a rheological agent for thickening or gelling the oil 莱雅公司 2020-11-06 CN disclosed
EP-2345456-B1 ANHYDROUS LIQUID SCREENING COMPOSITION CONTAINING AN OILY PHASE, A SPECIFIC TRIAZINE FILTER AND AN OILY REOLOGICAL THICKENING OR GELIFYING AGENT. L'ORÉAL (FR) 2017-05-03 EP disclosed
US-20120100089-A1 COSMETIC COMPOSITION FOR MAKEUP AND/OR KERATIN MATERIAL CARE, BASED ON A MIXTURE OF RESINS MQ AND T-PR, AND MAKEUP METHOD L'OREAL (FR) 2012-04-26 US disclosed
US-20120064019-A1 COSMETIC COMPOSITION FOR MAKING-UP AND/OR CARING FOR KERATIN MATERIALS AND MAKE-UP METHOD L'OREAL (FR) 2012-03-15 US disclosed
US-20120003167-A1 COSMETIC COMPOSITION COMPRISING SILOXANE RESINS AND AT LEAST ONE PHENYL SILICONE OIL L'OREAL (FR) 2012-01-05 US disclosed
EP-2373279-A2 COSMETIC COMPOSITION COMPRISING SILOXANE RESINS AND AT LEAST ONE PHENYLATED SILICONE OIL L'Oréal (FR) 2011-10-12 EP disclosed
EP-2373284-A2 COSMETIC COMPOSITION FOR MAKEUP AND/OR KERATIN MATERIAL CARE, BASED ON A MIXTURE OF RESINS MQ AND T-PR, AND MAKEUP METHOD L'Oréal (FR) 2011-10-12 EP disclosed
EP-2373285-A2 COSMETIC COMPOSITION FOR MAKING-UP AND/OR CARING FOR KERATIN MATERIALS AND MAKE-UP METHOD L'Oréal (FR) 2011-10-12 EP disclosed
WO-2010063957-A2 COSMETIC COMPOSITION FOR MAKING-UP AND/OR CARING FOR KERATIN MATERIALS AND MAKE-UP METHOD L'OREAL (FR) 2010-06-10 WO disclosed
WO-2010063968-A2 COSMETIC COMPOSITION FOR MAKING-UP AND/OR CARING FOR KERATIN MATERIAL AND MAKE-UP METHOD L'OREAL (FR) 2010-06-10 WO disclosed
WO-2010063966-A2 COSMETIC COMPOSITION FOR MAKEUP AND/OR KERATIN MATERIAL CARE, BASED ON A MIXTURE OF RESINS MQ AND T-PR, AND MAKEUP METHOD L'OREAL (FR) 2010-06-10 WO disclosed
WO-2010063967-A2 COSMETIC COMPOSITION FOR MAKING-UP AND/OR CARING FOR KERATIN MATERIAL AND MAKE-UP METHOD L'OREAL (FR) 2010-06-10 WO disclosed
WO-2010063965-A2 COSMETIC COMPOSITION FOR MAKING-UP AND/OR CARING FOR KERATIN MATERIAL AND MAKE-UP METHOD L'OREAL (FR) 2010-06-10 WO disclosed
EP-2135525-A2 Eyelash make-up and/or care kit L'Oréal (FR) 2009-12-23 EP disclosed
US-20060115445-A1 Compositions for treating keratin materials comprising electrophilic monomers and liquid crystal agents L'OREAL S.A. (FR) 2006-06-01 US disclosed
EP-1647259-A1 use for treatment of keratinic materials of compositions comprising electrophilic monomers and agents forming liquid crystals L'OREAL (FR) 2006-04-19 EP disclosed
US-6328910-B1 FOR IN SITU FORMATION OF AN POLYMERIC CYANOACRYLATE FILM ON MAMMALIAN SKIN WHICH CAN BE USED TO MONITOR THE SURFACE SKIN TEMPERATURE OF MAMMAL MEDLOGIC GLOBAL CORPORATION 2001-12-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120003167-A1 COSMETIC COMPOSITION COMPRISING SILOXANE RESINS AND AT LEAST ONE PHENYL SILICONE OIL QSOX1, RXRB, PRXL2A POLA1 726/4885CYP46A1 1898/4885OSBP 2210/4885
US-20060115445-A1 Compositions for treating keratin materials comprising electrophilic monomers and liquid crystal agents KRT18, PRKDC, CUTA POLA1 1396/4885CYP46A1 3561/4885OSBP 2396/4885
US-20120064019-A1 COSMETIC COMPOSITION FOR MAKING-UP AND/OR CARING FOR KERATIN MATERIALS AND MAKE-UP METHOD PLOD3, ALOX15, ELOVL1 POLA1 1182/4885CYP46A1 1271/4885OSBP 663/4885
US-20120100089-A1 COSMETIC COMPOSITION FOR MAKEUP AND/OR KERATIN MATERIAL CARE, BASED ON A MIXTURE OF RESINS MQ AND T-PR, AND MAKEUP METHOD KRT18, TERB1, VIM POLA1 433/4885CYP46A1 2471/4885OSBP 2405/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.