SCHEMBL3822262

SCHEMBL3822262

CCOC(=O)c1c2c(c3ccccc3c1C)OC(c1ccc(N3CCOCC3)cc1)(c1ccccc1OC)C=C2

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.40
LMNA P02545 3/20 0.40
NPSR1 Q6W5P4 2/20 0.40
DGAT1 O75907 12/20 0.39
SOAT1 P35610 10/20 0.39
MAPT P10636 4/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
GAA P10253 1/20 0.38
HPGD P15428 1/20 0.37
ALOX15 P16050 1/20 0.37
HSD17B10 Q99714 1/20 0.37
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3830804 0.89 ALDH1A1 (0.42) ALDH1A1LMNANPSR1DGAT1SOAT1
SCHEMBL4598178 0.81 MAPT (0.43) ALDH1A1LMNANPSR1DGAT1SOAT1
SCHEMBL29565421 0.81 MAPT (0.43) ALDH1A1LMNANPSR1DGAT1SOAT1
SCHEMBL5646820 0.79 DGAT1 (0.41) ALDH1A1LMNANPSR1DGAT1SOAT1
SCHEMBL4598124 0.77 ALDH1A1 (0.49) ALDH1A1NPSR1DGAT1SOAT1HPGD
SCHEMBL2466409 0.76 PKM (0.41) ALDH1A1LMNAMAPTRAB9AGAA
SCHEMBL5160384 0.75 MAPT (0.40) ALDH1A1LMNAMAPTNPC1RAB9A
SCHEMBL3164927 0.74 MAPT (0.41) ALDH1A1MAPTNPC1RAB9AGAA
SCHEMBL29565400 0.74 MAPT (0.41) ALDH1A1MAPTNPC1RAB9AGAA
SCHEMBL7971543 0.73 KIF11 (0.40) ALDH1A1LMNAMAPTNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1707610-B1 Photochromic polymerizable composition TOKUYAMA CORP (JP) 2009-09-09 EP claimed
US-6362248-B1 MIXTURE OF (METH)ACRYLATE MONOMER AND CHROMENE COMPOUND TOKUYAMA CORPORATION (JP) 2002-03-26 US claimed
EP-1707610-B1 Photochromic polymerizable composition TOKUYAMA CORP (JP) 2009-09-09 EP disclosed
EP-1707610-A2 Photochromic polymerizable composition Tokuyama Corporation (JP) 2006-10-04 EP disclosed
US-6362248-B1 MIXTURE OF (METH)ACRYLATE MONOMER AND CHROMENE COMPOUND TOKUYAMA CORPORATION (JP) 2002-03-26 US disclosed
EP-0984053-A1 PHOTOCHROMIC POLYMERIZABLE COMPOSITION TOKUYAMA CORPORATION (JP) 2000-03-08 EP disclosed