Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.31 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.31 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.30 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.30 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5157157 | 0.98 | RAPGEF4 (0.33) | RAB9ALMNAHTTSMN1; SMN2RAPGEF4 | |
| SCHEMBL6454170 | 0.90 | PABPC1 (0.47) | RAB9ALMNAHTTSMN1; SMN2PABPC1 | |
| SCHEMBL5154730 | 0.90 | SLC6A4 (0.45) | PABPC1APOBEC3AEIF4HAPOBEC3GSLC22A2 | |
| Hydrochloric Acid SCHEMBL193608 | 0.89 | PABPC1 (0.46) | RAB9ALMNAHTTSMN1; SMN2PABPC1 | |
| Hydrochloric Acid SCHEMBL2462196 | 0.80 | ALDH1A1 (0.65) | RAB9ALMNAHTTSMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL3143919 | 0.79 | CYP2A6 (0.36) | RAB9AKDM4EALDH1A1PABPC1APOBEC3A | |
| Hydrochloric Acid SCHEMBL2258996 | 0.78 | FDPS (0.32) | LMNAHTTSMN1; SMN2KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL604112 | 0.78 | PGK1 (0.33) | RAB9AKDM4EALDH1A1 | |
| SCHEMBL5159445 | 0.76 | CYP2A6 (0.38) | RAB9AKDM4EALDH1A1CYP1A2CYP2A6 | |
| SCHEMBL28575906 | 0.76 | RAPGEF4 (0.35) | LMNAKDM4EALDH1A1RAPGEF4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8014056-B2 | Display element and method of driving the same | KONICA MINOLTA HOLDINGS, INC. (JP) | 2011-09-06 | — | — | US | disclosed |
| US-20100091353-A1 | DISPLAY ELEMENT AND METHOD OF DRIVING THE SAME | KONICA MINOLTA HOLDINGS, INC. (JP) | 2010-04-15 | — | — | US | disclosed |
| EP-2096490-A1 | DISPLAY ELEMENT AND METHOD OF DRIVING THE SAME | Konica Minolta Holdings, Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |