Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.36 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.32 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5159445 | 0.98 | CYP2A6 (0.38) | CYP2A6CYP1A2TRPA1SLC22A2SLC22A1 | |
| Hydrochloric Acid SCHEMBL2463158 | 0.81 | ALDH1A1 (0.64) | ALDH1A1KDM4ERAB9A | |
| SCHEMBL19601136 | 0.80 | CA12 (0.33) | CA1CA2CA9 | |
| Hydrochloric Acid SCHEMBL2469452 | 0.79 | RAB9A (0.33) | CYP2A6CYP1A2SLC22A2SLC22A1SLC22A3 | |
| SCHEMBL19888150 | 0.71 | ACHE (0.44) | CYP2A6CYP1A2TRPA1SLC22A2SLC22A1 | |
| SCHEMBL6454170 | 0.71 | PABPC1 (0.47) | RAB9APABPC1APOBEC3AEIF4HAPOBEC3G | |
| Hydrochloric Acid SCHEMBL1737122 | 0.71 | GABRA1 (0.41) | CYP1A2SLC22A2SLC22A1SLC22A3SLC6A4 | |
| Hydrochloric Acid SCHEMBL193608 | 0.70 | PABPC1 (0.46) | RAB9APABPC1APOBEC3AEIF4HAPOBEC3G | |
| SCHEMBL5154730 | 0.70 | SLC6A4 (0.45) | SLC22A2SLC22A1SLC22A3SLC6A4PABPC1 | |
| SCHEMBL13397530 | 0.68 | GABRA1 (0.43) | CYP1A2SLC22A2SLC22A1SLC22A3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100091353-A1 | DISPLAY ELEMENT AND METHOD OF DRIVING THE SAME | KONICA MINOLTA HOLDINGS, INC. (JP) | 2010-04-15 | — | — | US | disclosed |
| EP-2096490-A1 | DISPLAY ELEMENT AND METHOD OF DRIVING THE SAME | Konica Minolta Holdings, Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |