SCHEMBL248238

SCHEMBL248238

c1ccc([C@@H]2COC(CC3=N[C@H](c4ccccc4)CO3)=N2)cc1

nearest known ligand 0.59

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 6/20 0.59
MAPT P10636 2/20 0.49
ALDH1A1 P00352 2/20 0.46
NPC1 O15118 2/20 0.46
RAB9A P51151 2/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
POLB P06746 1/20 0.43
LMNA P02545 1/20 0.42
HTT P42858 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL820194 1.00 TAAR1 (0.59) TAAR1MAPTALDH1A1NPC1RAB9A
SCHEMBL10302995 1.00 TAAR1 (0.59) TAAR1MAPTALDH1A1NPC1RAB9A
SCHEMBL1130128 1.00 TAAR1 (0.59) TAAR1MAPTALDH1A1NPC1RAB9A
SCHEMBL23393910 0.87 TAAR1 (0.47) TAAR1MAPTALDH1A1NPC1RAB9A
SCHEMBL23054771 0.87 TAAR1 (0.47) TAAR1MAPTALDH1A1NPC1RAB9A
SCHEMBL21444969 0.86 TAAR1 (0.46) TAAR1MAPTALDH1A1NPC1RAB9A
SCHEMBL4587339 0.85 TAAR1 (0.56) TAAR1MAPTALDH1A1NPC1RAB9A
SCHEMBL4416002 0.85 TAAR1 (0.56) TAAR1MAPTALDH1A1NPC1RAB9A
SCHEMBL13788689 0.85 TAAR1 (0.56) TAAR1MAPTALDH1A1NPC1RAB9A
SCHEMBL4586186 0.85 TAAR1 (0.56) TAAR1MAPTALDH1A1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116354802-A Preparation method of chiral benzyl secondary alcohol compound 上海毕得医药科技股份有限公司 2023-06-30 CN claimed
CN-111548329-B Preparation method of brivaracetam 浙江乐普药业股份有限公司 2022-06-17 CN claimed
CN-111548329-A Preparation method of brivaracetam 浙江乐普药业股份有限公司 2020-08-18 CN claimed
CN-116354802-A Preparation method of chiral benzyl secondary alcohol compound 上海毕得医药科技股份有限公司 2023-06-30 CN disclosed
CN-111548329-B Preparation method of brivaracetam 浙江乐普药业股份有限公司 2022-06-17 CN disclosed
EP-3896058-A2 ENANTIONSELECTIVE PROCESSES TO INSECTICIDAL 3-ARYL-3-TRIFLUOROMETHYL-SUBSTITUTED PYRROLIDINES SYNGENTA PARTICIPATIONS AG (CH) 2021-10-20 EP disclosed
EP-2763963-B1 ENANTIONSELECTIVE PROCESSES TO INSECTICIDAL 3-ARYL-3-TRIFLUOROMETHYL-SUBSTITUTED PYRROLIDINES SYNGENTA PARTICIPATIONS AG (CH) 2021-05-26 EP disclosed
CN-111548329-A Preparation method of brivaracetam 浙江乐普药业股份有限公司 2020-08-18 CN disclosed
US-9469633-B2 Processes for the preparation of pyrrolidine intermediates SYNGENTA PARTICIPATIONS AG (CH) 2016-10-18 US disclosed
US-9469633-B2 Processes for the preparation of pyrrolidine intermediates SYNGENTA PARTICIPATIONS AG (CH) 2016-10-18 US disclosed
US-20140350301-A1 NOVEL PROCESSES FOR THE PREPARATION OF PHENYLCYCLOPROPYLAMINE DERIVATIVES AND USE THEREOF FOR PREPARING TICAGRELOR ACTAVIS GROUP PTC EHF (IS) 2014-11-27 US disclosed
US-20110009609-A1 2'-HYDROXY-PROTECTED RIBONUCLEOSIDE DERIVATIVE AND PRODUCTION METHOD THEREOF KANEKA CORPORATION (JP) 2011-01-13 US disclosed
EP-2258709-A1 2'-HYDROXYL-PROTECTED RIBONUCLEOSIDE DERIVATIVE AND MANUFACTURING METHOD OF SAME Kaneka Corporation (JP) 2010-12-08 EP disclosed
EP-1253135-B1 Asymmetric copper complex and cyclopropanation reaction using the same SUMITOMO CHEMICAL CO (JP) 2010-11-24 EP disclosed
US-20100056806-A1 C-H Bond Amination and Olefin Aziridination with Beta-Diketiminato Copper Catalysts GEORGETOWN UNIVERSITY (US) 2010-03-04 US disclosed
US-6858559-B2 Using copper complex containing oxazole molecules SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-02-22 US disclosed
US-20020177718-A1 Asymmetric copper complex and cyclopropanation reaction using the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-11-28 US disclosed
EP-1253135-A1 Asymmetric copper complex and cyclopropanation reaction using the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-10-30 EP disclosed
US-20020123645-A1 Method for producing optically active chrysanthemic acid SUMITOMO CHEMICAL COMPANY, LIMITED 2002-09-05 US disclosed
EP-1236708-A1 Method for producing optically active chrysanthemic acid SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-09-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020123645-A1 Method for producing optically active chrysanthemic acid ENO1, CYP8B1, CRYAA TAAR1 4555/4885MAPT 1433/4885ALDH1A1 1283/4885
US-20140350301-A1 NOVEL PROCESSES FOR THE PREPARATION OF PHENYLCYCLOPROPYLAMINE DERIVATIVES AND USE THEREOF FOR PREPARING TICAGRELOR THPO, P2RY4, TBXA2R TAAR1 795/4885MAPT 3525/4885ALDH1A1 1717/4885
US-20100056806-A1 C-H Bond Amination and Olefin Aziridination with Beta-Diketiminato Copper Catalysts AOC2, AOC1, AOC3 TAAR1 1993/4885MAPT 4498/4885ALDH1A1 20/4885
US-20110009609-A1 2'-HYDROXY-PROTECTED RIBONUCLEOSIDE DERIVATIVE AND PRODUCTION METHOD THEREOF RNASEL, RNASEH1, NUDT1 TAAR1 4350/4885MAPT 4735/4885ALDH1A1 357/4885
US-20020177718-A1 Asymmetric copper complex and cyclopropanation reaction using the same AOC3, AOC1, ACSL3 TAAR1 1431/4885MAPT 4820/4885ALDH1A1 602/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.