Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | GRK2 | P25098 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | SCN4A | P35499 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3483992 | 0.80 | NR1H2 (0.67) | XDHCLK4NOTUMDYRK1ANR1H2 | |
| SCHEMBL15117068 | 0.80 | KDM4E (0.67) | XDHKDM4ECLK4MEN1KMT2A | |
| SCHEMBL1036436 | 0.80 | HDAC3 (0.53) | XDHKDM4ECLK4MEN1KMT2A | |
| SCHEMBL19127978 | 0.79 | KDM4E (0.56) | XDHKDM4ECLK4MEN1KMT2A | |
| SCHEMBL1041941 | 0.76 | ROCK2 (0.57) | XDHKDM4ECLK4MEN1KMT2A | |
| SCHEMBL7200528 | 0.76 | NR1H2 (0.56) | NOTUMTP53ROCK2GRK2NPC1 | |
| SCHEMBL657644 | 0.75 | NR1H2 (0.61) | MEN1KMT2AMAPTTP53NPC1 | |
| SCHEMBL15025693 | 0.75 | NR1H2 (0.73) | KDM4EMEN1KMT2AMAPTTP53 | |
| SCHEMBL338452 | 0.74 | CLK4 (0.64) | XDHKDM4ECLK4MEN1KMT2A | |
| SCHEMBL15025694 | 0.73 | KDM4E (0.58) | KDM4EKMT2AMAPTTP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9376402-B2 | 1, 2, 4-triazole derivatives and their anti-microbial activity | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-06-28 | — | — | US | disclosed |
| CN-102858755-B | 1,2,4-triazole derivative and anti-mycobacterium activity thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-11-25 | — | — | CN | disclosed |
| US-20150073026-A1 | 1, 2, 4-TRIAZOLE DERIVATIVES AND THEIR ANTI-MICROBIAL ACTIVITY | COUNCIL SCIENT IND RES (IN) | 2015-03-12 | — | — | US | disclosed |
| US-8865910-B2 | 1, 2, 4-triazole derivatives and their anti mycobacterial activity | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-10-21 | — | — | US | disclosed |
| US-20140275224-A1 | CYTOSINE DEAMINASE MODULATORS FOR ENHANCEMENT OF DNA TRANSFECTION | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2014-09-18 | — | — | US | disclosed |
| US-20140275224-A1 | CYTOSINE DEAMINASE MODULATORS FOR ENHANCEMENT OF DNA TRANSFECTION | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2014-09-18 | — | — | US | disclosed |
| WO-2013074059-A2 | CYTOSINE DEAMINASE MODULATORS FOR ENHANCEMENT OF DNA TRANSFECTION | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2013-05-23 | — | — | WO | disclosed |
| US-20130060045-A1 | 1, 2, 4-TRIAZOLE DERIVATIVES AND THEIR ANTI MYCOBACTERIAL ACTIVITY | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2013-03-07 | — | — | US | disclosed |
| CN-102858755-A | 1, 2, 4-triazole derivatives and their anti mycobacterial activity | COUNCIL SCIENT IND RES | 2013-01-02 | — | — | CN | disclosed |
| WO-2011111077-A1 | 1, 2, 4-TRIAZOLE DERIVATIVES AND THEIR ANTI MYCOBACTERIAL ACTIVITY | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2011-09-15 | — | — | WO | disclosed |
| US-20100004159-A1 | SUBSTITUTED IMIDAZOLONE DERIVATIVES, PREPARATIONS AND USES | GENFIT (FR) | 2010-01-07 | — | — | US | disclosed |
| CN-101522192-A | Substituted imidazolone derivatives, preparation and uses | GENFIT (FR) | 2009-09-02 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004159-A1 | SUBSTITUTED IMIDAZOLONE DERIVATIVES, PREPARATIONS AND USES | IPO5, PPIP5K2, IPO4 | XDH 628/4885KDM4E 2600/4885CLK4 1179/4885 |
| US-20130060045-A1 | 1, 2, 4-TRIAZOLE DERIVATIVES AND THEIR ANTI MYCOBACTERIAL ACTIVITY | NAT1, CBR3, NOX3 | XDH 31/4885KDM4E 4437/4885CLK4 3141/4885 |
| US-20150073026-A1 | 1, 2, 4-TRIAZOLE DERIVATIVES AND THEIR ANTI-MICROBIAL ACTIVITY | CYP51A1, TALDO1, IL33 | XDH 357/4885KDM4E 4127/4885CLK4 2312/4885 |
| US-20140275224-A1 | CYTOSINE DEAMINASE MODULATORS FOR ENHANCEMENT OF DNA TRANSFECTION | CDA, DCTD, ADA | XDH 756/4885KDM4E 1984/4885CLK4 4701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.