Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24937259 | 0.88 | SMN1; SMN2 (0.39) | SMN1; SMN2CYP3A4USP2MAPTALDH1A1 | |
| SCHEMBL23123688 | 0.83 | CYP3A4 (0.37) | SMN1; SMN2CYP3A4USP2MAPTALDH1A1 | |
| SCHEMBL24936579 | 0.79 | TSHR (0.37) | SMN1; SMN2MAPTALDH1A1NPSR1LMNA | |
| SCHEMBL27077700 | 0.76 | ALDH1A1 (0.47) | SMN1; SMN2CYP3A4USP2MAPTALDH1A1 | |
| SCHEMBL23122981 | 0.72 | DGAT1 (0.35) | SMN1; SMN2CYP3A4USP2MAPTALDH1A1 | |
| SCHEMBL29987804 | 0.72 | ALDH1A1 (0.43) | SMN1; SMN2CYP3A4USP2MAPTALDH1A1 | |
| SCHEMBL21266229 | 0.70 | GAA (0.39) | SMN1; SMN2MAPTALDH1A1NPSR1GAA | |
| SCHEMBL19149856 | 0.70 | HTT (0.34) | SMN1; SMN2MAPTALDH1A1NPSR1HTT | |
| SCHEMBL19149345 | 0.68 | GABRA2 (0.32) | SMN1; SMN2MAPTALDH1A1HTTKMT2A | |
| SCHEMBL18676310 | 0.68 | LMNA (0.35) | SMN1; SMN2MAPTALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230028114-A1 | AZOLE-FUSED PYRIDAZIN-3(2H)-ONE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230028114-A1 | AZOLE-FUSED PYRIDAZIN-3(2H)-ONE DERIVATIVES | GPR139, GPR119, GPR39 | SMN1; SMN2 2406/4885CYP3A4 1477/4885USP2 4026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.