Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6280282 | 0.92 | MTNR1A (0.51) | NPC1RAB9ASMN1; SMN2HDAC6HDAC3 | |
| SCHEMBL11599893 | 0.91 | ALDH1A1 (0.59) | NPC1RAB9ASMN1; SMN2HDAC6HDAC3 | |
| SCHEMBL7455676 | 0.91 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2HDAC6HDAC3 | |
| SCHEMBL8597033 | 0.91 | ALDH1A1 (0.52) | NPC1RAB9ASMN1; SMN2HDAC6HDAC3 | |
| SCHEMBL5043303 | 0.90 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2HDAC6HDAC3 | |
| SCHEMBL29766169 | 0.90 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2HDAC6HDAC3 | |
| SCHEMBL5045385 | 0.90 | ALDH1A1 (0.56) | NPC1RAB9ASMN1; SMN2HDAC6HDAC3 | |
| SCHEMBL30610971 | 0.90 | ALDH1A1 (0.56) | NPC1RAB9ASMN1; SMN2HDAC6HDAC3 | |
| SCHEMBL5685556 | 0.89 | RAB9A (0.53) | NPC1RAB9ASMN1; SMN2HDAC6HDAC3 | |
| SCHEMBL6281255 | 0.89 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 125 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132194-A1 | PROCESS FOR THE PREPARATION OF RALOXIFENE HYDROCHLORIDE | HETERO RESEARCH FOUNDATION (IN) | 2011-10-27 | — | — | WO | claimed |
| US-7385087-B2 | Method for producing a-(3-arylthio)-acetophenones | BASF AKTIENGESELLSCHAFT (DE) | 2008-06-10 | — | — | US | claimed |
| EP-1678127-B1 | METHOD FOR THE PRODUCTION OF ALPHA-(3-ARYLTHIO)-ACETOPHENONES | BASF AG (DE) | 2007-07-25 | — | — | EP | claimed |
| US-20070060776-A1 | Method for the production of alpha-(3-arylthio)-acetophenones | BASF AKTIENGESELLSCHAFT (DE) | 2007-03-15 | — | — | US | claimed |
| EP-1603868-B1 | METHOD FOR PRODUCING ALPHA-(3-ARYLTHIO)-ACETOPHENONES | BASF AG (DE) | 2006-09-13 | — | — | EP | claimed |
| US-20060178537-A1 | Method for producing a-(3-arylthio)-acetophenones | BASF AKTIENGESELLSCHAFT (DE) | 2006-08-10 | — | — | US | claimed |
| EP-1603868-A1 | METHOD FOR PRODUCING a-(3-ARYLTHIO)-ACETOPHENONES | BASF AKTIENGESELLSCHAFT (DE) | 2005-12-14 | — | — | EP | claimed |
| WO-2004078705-A1 | METHOD FOR PRODUCING α-(3-ARYLTHIO)-ACETOPHENONES | BASF AKTIENGESELLSCHAFT (DE) | 2004-09-16 | — | — | WO | claimed |
| CN-112174793-B | Method and ligand for breaking C-S bond of alpha-thioaryl ethanone compound | 温州大学 | 2023-03-28 | — | — | CN | disclosed |
| CN-112174793-A | Method and ligand for breaking C-S bond of alpha-thioaryl ethanone compound | 温州大学 | 2021-01-05 | — | — | CN | disclosed |
| WO-2011132194-A1 | PROCESS FOR THE PREPARATION OF RALOXIFENE HYDROCHLORIDE | HETERO RESEARCH FOUNDATION (IN) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011132194-A1 | PROCESS FOR THE PREPARATION OF RALOXIFENE HYDROCHLORIDE | HETERO RESEARCH FOUNDATION (IN) | 2011-10-27 | — | — | WO | disclosed |
| US-8030330-B2 | Benzothiophenes, formulations containing same, and methods | ELI LILLY AND COMPANY (US) | 2011-10-04 | — | — | US | disclosed |
| US-20100255106-A1 | BENZOTHIOPHENES, FORMULATIONS CONTAINING SAME, AND METHODS | ARBUTHNOT GORDON NELSON | 2010-10-07 | — | — | US | disclosed |
| US-4380635-A | Synthesis of acylated benzothiophenes | ELI LILLY AND COMPANY (US) | 1983-04-19 | — | — | US | disclosed |
| US-4358593-A | BY ACYLATION OF PROTECTED 6-HYDROXY,2-(4-HYDROXYPHENYL) BENZO (B)THIOPHENE USING A FRIEDEL CRAFTS CATALYSTS; HYDROLYSIS | ELI LILLY AND COMPANY (US) | 1982-11-09 | — | — | US | disclosed |
| EP-0062503-A1 | Benzothiophene compounds and process for preparing them | ELI LILLY AND COMPANY (US) | 1982-10-13 | — | — | EP | disclosed |
| EP-0062505-A1 | A process for preparing acylated benzothiophenes | ELI LILLY AND COMPANY (US) | 1982-10-13 | — | — | EP | disclosed |
| EP-0062504-A1 | Process for preparing 3-(4-aminoethoxybenzoyl)benzo(b)thiophenes | ELI LILLY AND COMPANY (US) | 1982-10-13 | — | — | EP | disclosed |
| US-4133814-A | ANTITUMOR AGENTS | ELI LILLY AND COMPANY (US) | 1979-01-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060776-A1 | Method for the production of alpha-(3-arylthio)-acetophenones | CBR3, CYB5R3, ME3 | NPC1 3802/4885RAB9A 2474/4885SMN1; SMN2 4359/4885 |
| US-20060178537-A1 | Method for producing a-(3-arylthio)-acetophenones | ARSA, TST, SULT1A1 | NPC1 3888/4885RAB9A 4071/4885SMN1; SMN2 4159/4885 |
| US-20100255106-A1 | BENZOTHIOPHENES, FORMULATIONS CONTAINING SAME, AND METHODS | BRCA1, CYP19A1, CYP46A1 | NPC1 25/4885RAB9A 3416/4885SMN1; SMN2 3033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.