Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 3/20 | 0.60 |
| ▸ | CA2 | P00918 | 3/20 | 0.60 |
| ▸ | CA9 | Q16790 | 3/20 | 0.60 |
| ▸ | CA1 | P00915 | 2/20 | 0.60 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP7 | P09237 | 1/20 | 0.50 |
| ▸ | MMP14 | P50281 | 1/20 | 0.50 |
| ▸ | UQCRB | P14927 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | PARL | Q9H300 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8662029 | 0.95 | CA12 (0.60) | CA12CA2CA9CA1MMP2 | |
| SCHEMBL11327611 | 0.95 | CA12 (0.60) | CA12CA2CA9CA1MMP2 | |
| SCHEMBL11746260 | 0.95 | CA12 (0.60) | CA12CA2CA9CA1MMP2 | |
| Potassium Ion SCHEMBL9302660 | 0.89 | CA12 (0.52) | CA12CA2CA9CA1MMP2 | |
| Potassium Ion SCHEMBL5847292 | 0.89 | CA12 (0.52) | CA12CA2CA9CA1MMP2 | |
| Potassium Ion SCHEMBL1416239 | 0.87 | HTR6 (0.55) | CA12CA2CA9CA1MMP2 | |
| Potassium Ion SCHEMBL28525357 | 0.87 | HTR6 (0.55) | CA12CA2CA9CA1MMP2 | |
| Potassium Ion SCHEMBL132447 | 0.87 | HTR6 (0.55) | CA12CA2CA9CA1MMP2 | |
| Potassium Ion SCHEMBL28218945 | 0.84 | HTR6 (0.52) | CA12CA2CA9CA1MMP2 | |
| SCHEMBL3171668 | 0.84 | CA12 (0.52) | CA12CA2CA9CA1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110248223-A1 | Additives for Enhancing the Antistatic Properties of Conductive Polymer-Based Coatings | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2011-10-13 | — | — | US | disclosed |
| EP-2370527-A1 | ADDITIVES FOR ENHANCING THE ANTISTATIC PROPERTIES OF CONDUCTIVE POLYMER-BASED COATINGS | Essilor International (Compagnie Générale D'Optique) (FR) | 2011-10-05 | — | — | EP | disclosed |