Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ACACB | O00763 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 8/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | LIPE | Q05469 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13181088 | 0.91 | ALDH1A1 (0.52) | ALDH1A1RAB9AACACBPPARGPPARA | |
| SCHEMBL14349927 | 0.87 | P2RX3 (0.48) | HTTL3MBTL1HAO1KDM4EP2RX3 | |
| SCHEMBL27691056 | 0.86 | L3MBTL1 (0.43) | ALDH1A1HTTL3MBTL1HAO1CYP3A4 | |
| SCHEMBL8515025 | 0.84 | MEN1 (0.55) | ALDH1A1RAB9AACACBHTTL3MBTL1 | |
| SCHEMBL15685061 | 0.84 | MAOB (0.55) | RAB9AHTTL3MBTL1HAO1KDM4E | |
| SCHEMBL18798976 | 0.84 | THRB (0.50) | ALDH1A1RAB9AACACBL3MBTL1KDM4E | |
| SCHEMBL15177164 | 0.84 | ACACB (0.47) | ACACBOPRM1OPRD1OPRK1 | |
| SCHEMBL9045495 | 0.84 | OPRM1 (0.45) | KDM4EP2RX3OPRM1OPRD1OPRK1 | |
| SCHEMBL23252933 | 0.84 | TAAR1 (0.56) | ACACBCYP3A4P2RX3OPRM1OPRD1 | |
| SCHEMBL9829679 | 0.82 | L3MBTL1 (0.45) | ALDH1A1HTTL3MBTL1HAO1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230043159-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | DISC MEDICINE, INC. | 2023-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230043159-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | MMP7, MATR3, SPINT2 | ALDH1A1 3877/4885RAB9A 4274/4885ACACB 1507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.