Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | CTSV | O60911 | 6/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | SNCA | P37840 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20389071 | 0.79 | ALKBH5 (0.43) | MAPTKDM4EALDH1A1CYP1A2LMNA | |
| SCHEMBL30706223 | 0.78 | LMNA (0.37) | MAPTHTTKDM4EHPGDHSD17B10 | |
| SCHEMBL7360572 | 0.74 | HTR3A (0.52) | MAPTHTR3AHTTCTSVKDM4E | |
| SCHEMBL31554686 | 0.71 | GAA (0.48) | MAPTALDH1A1GAATSHRTDP1 | |
| SCHEMBL5565026 | 0.68 | GPR3 (0.44) | KDM4EHSD17B10ALDH1A1TSHR | |
| SCHEMBL31172010 | 0.68 | GPR3 (0.44) | KDM4EHSD17B10ALDH1A1TSHR | |
| SCHEMBL25079226 | 0.66 | ADORA3 (0.40) | MAPTHTR3AAPPTDP1 | |
| SCHEMBL31575008 | 0.66 | LMNA (0.33) | THRBLMNATP53 | |
| SCHEMBL31569813 | 0.66 | RXFP1 (0.36) | MAPTLMNA | |
| SCHEMBL31330822 | 0.64 | L3MBTL1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023023531-A1 | ESTROGEN RECEPTOR DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2023-02-23 | — | — | WO | disclosed |