SCHEMBL2520403

SCHEMBL2520403

NCc1ccc(Br)c(Cl)c1

nearest known ligand 0.50

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CSNK2A1 P68400 10/20 0.50
PNMT P11086 2/20 0.45
TAAR1 Q96RJ0 2/20 0.43
CSNK2A2 P19784 1/20 0.43
CSNK2B P67870 1/20 0.43
CSNK2A3 Q8NEV1 1/20 0.43
LOXL2 Q9Y4K0 2/20 0.42
LOX P28300 1/20 0.42
LOXL3 P58215 1/20 0.42
CYP3A4 P08684 1/20 0.40
HRH3 Q9Y5N1 1/20 0.39
IDO1 P14902 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30003904 1.00 CSNK2A1 (0.50) CSNK2A1PNMTTAAR1CSNK2A2CSNK2B
Hydrochloric Acid SCHEMBL30051933 0.98 CSNK2A1 (0.52) CSNK2A1PNMTTAAR1CSNK2A2CSNK2B
SCHEMBL17186197 0.83 TAAR1 (0.67) PNMTTAAR1
SCHEMBL1363230 0.82 CSNK2A1 (0.46) CSNK2A1PNMTTAAR1CSNK2A2CSNK2B
SCHEMBL1535743 0.79 IDO1 (0.38) PNMTTAAR1CYP3A4IDO1
SCHEMBL507688 0.79 CYP4F2 (0.40) PNMTTAAR1CYP3A4IDO1
SCHEMBL29349576 0.78 PNMT (0.67) CSNK2A1PNMTTAAR1CSNK2A2CSNK2B
SCHEMBL112200 0.78 PNMT (0.67) CSNK2A1PNMTTAAR1CSNK2A2CSNK2B
SCHEMBL28958238 0.78 HRH3 (0.43) CSNK2A1PNMTTAAR1LOXL2LOX
SCHEMBL29875339 0.78 HRH3 (0.43) CSNK2A1PNMTTAAR1LOXL2LOX

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026107227-A1 COMPOSITIONS COMPRISING USP1 INHIBITORS AND METHODS OF USING THE SAME EIKON THERAPEUTICS, INC. (US) 2026-05-21 WO disclosed
US-12516039-B2 N-linked isoquinoline amides as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof MERCK SHARP & DOHME LLC (US) 2026-01-06 US disclosed
US-20240398784-A1 C-LINKED ISOQUINOLINE AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF MERCK SHARP & DOHME LLC (US) 2024-12-05 US disclosed
EP-4408427-A1 SYSTEM AND METHOD FOR STATIC AND DYNAMIC MRI SHIMMING Merck Sharp & Dohme LLC (US) 2024-08-07 EP disclosed
US-20240016942-A1 STAT DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2024-01-18 US disclosed
US-20240016942-A1 STAT DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2024-01-18 US disclosed
US-20230406844-A1 N-LINKED ISOQUINOLINE AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF MERCK SHARP & DOHME LLC (US) 2023-12-21 US disclosed
US-20230357214-A1 NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY PHENEX PHARMACEUTICALS AKTIENGESELLSCHAFT (DE) 2023-11-09 US disclosed
US-20230357214-A1 NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY PHENEX PHARMACEUTICALS AKTIENGESELLSCHAFT (DE) 2023-11-09 US disclosed
US-20230303540-A1 2-AMINOQUINAZOLINES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF MERCK SHARP & DOHME LLC (US) 2023-09-28 US disclosed
US-20180208580-A1 ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF VICKERS VENTURE FUND VI PTE. LTD. (SG) 2018-07-26 US disclosed
US-20180155323-A1 ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF TENARX, INC. 2018-06-07 US disclosed
US-9951048-B1 Isoquinolin-3-yl carboxamides and preparation and use thereof SAMUMED, LLC (US) 2018-04-24 US disclosed
US-20180093970-A1 ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF TENARX, INC. 2018-04-05 US disclosed
US-20170313682-A1 ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF TENARX, INC. 2017-11-02 US disclosed
US-20170313681-A1 ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF VICKERS VENTURE FUND VI PTE. LTD. (SG) 2017-11-02 US disclosed
US-20170313681-A1 ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF VICKERS VENTURE FUND VI PTE. LTD. (SG) 2017-11-02 US disclosed
US-20170313682-A1 ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF TENARX, INC. 2017-11-02 US disclosed
US-20110251173-A1 CHEMICAL COMPOUNDS ASTRAZENECA AB (SE) 2011-10-13 US disclosed
WO-2011121350-A1 4 -AMINO -7,8- DIHYDROPYRIMIDO [5, 4 - F] [1, 4] OXAZEPIN- 5 ( 6H) - ONE BASED DGAT1 INHIBITORS ASTRAZENECA AB (SE) 2011-10-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180093970-A1 ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF WNT1, WNT3, WNT3A CSNK2A1 144/4885PNMT 3422/4885TAAR1 4856/4885
US-20170313681-A1 ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF DYRK1A, DYRK3, DYRK1B CSNK2A1 26/4885PNMT 3571/4885TAAR1 3513/4885
US-20240016942-A1 STAT DEGRADERS AND USES THEREOF STAT4, STAT1, STAT3 CSNK2A1 84/4885PNMT 3421/4885TAAR1 2149/4885
US-20180155323-A1 ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF WNT1, WNT3, WNT3A CSNK2A1 144/4885PNMT 3422/4885TAAR1 4856/4885
US-20230303540-A1 2-AMINOQUINAZOLINES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF LRRK2, CLK2, BRSK2 CSNK2A1 38/4885PNMT 2574/4885TAAR1 3490/4885
US-20230357214-A1 NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY NR1H2, NR1H3, NR1H4 CSNK2A1 1000/4885PNMT 4375/4885TAAR1 712/4885
US-20230406844-A1 N-LINKED ISOQUINOLINE AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF LRRK2, BRSK2, CLK2 CSNK2A1 74/4885PNMT 1973/4885TAAR1 4003/4885
US-20110251173-A1 CHEMICAL COMPOUNDS DGAT1, DGAT2, SLC5A1 CSNK2A1 2229/4885PNMT 1252/4885TAAR1 1061/4885
US-20180208580-A1 ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF DYRK1A, DYRK3, DYRK1B CSNK2A1 26/4885PNMT 3571/4885TAAR1 3513/4885
US-20240398784-A1 C-LINKED ISOQUINOLINE AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF LRRK2, CLK2, BRSK2 CSNK2A1 30/4885PNMT 2573/4885TAAR1 4174/4885
US-20170313682-A1 ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF WNT1, WNT3, WNT3A CSNK2A1 144/4885PNMT 3422/4885TAAR1 4856/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.