SCHEMBL25400578

SCHEMBL25400578

CC(=O)c1ccn2c(C(C)=O)cc(Br)c2c1

nearest known ligand 0.45

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ BAZ2B Q9UIF8 17/20 0.45
▸ BAZ2A Q9UIF9 17/20 0.45
▸ ALDH1A1 P00352 1/20 0.40
▸ BRD9 Q9H8M2 3/20 0.39
▸ BRD4 O60885 2/20 0.39
▸ BRD2 P25440 1/20 0.39
▸ BRD3 Q15059 1/20 0.39
▸ MAPT P10636 2/20 0.36
▸ TP53 P04637 1/20 0.36
▸ THRB P10828 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25401220 0.85 FNTA (0.51) BAZ2BBAZ2AALDH1A1BRD4BRD2
SCHEMBL25402588 0.81 LMNA (0.46) ALDH1A1MAPTTP53
SCHEMBL29547188 0.80 ALDH1A1 (0.40) ALDH1A1MAPT
SCHEMBL24510741 0.80 BAZ2B (0.57) BAZ2BBAZ2AALDH1A1BRD9TP53
SCHEMBL25399546 0.78 BAZ2B (0.38) BAZ2BBAZ2AALDH1A1BRD9BRD4
SCHEMBL25401668 0.78 BAZ2B (0.62) BAZ2BBAZ2ABRD9BRD4BRD2
SCHEMBL25400534 0.78 MAPT (0.43) ALDH1A1MAPTTP53
SCHEMBL26302021 0.78 BAZ2B (0.54) BAZ2BBAZ2ABRD9BRD4BRD2
SCHEMBL26302067 0.72 BAZ2B (0.53) BAZ2BBAZ2ABRD9TP53
SCHEMBL26302073 0.72 BAZ2B (0.71) BAZ2BBAZ2AALDH1A1BRD9BRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4233864-B1 COMPOSITION COMPRISING AN INDOLIZINE DERIVATIVE AND A CYCLIC DINUCLEOTIDE AS ACTIVE AGENTS UNIV AJOU IND ACADEMIC COOP FOUND (KR) 2025-02-12 — — EP disclosed
US-20230390319-A1 INTERFERON GENE STIMULATOR COMPOSITION COMPRISING INDOLIZINE DERIVATIVE AS ACTIVE INGREDIENT KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2023-12-07 — — US disclosed
EP-4233864-A1 INTERFERON GENE STIMULATOR COMPOSITION COMPRISING INDOLIZINE DERIVATIVE AS ACTIVE INGREDIENT Ajou University Industry-Academic Cooperation Foundation (KR) 2023-08-30 — — EP disclosed
WO-2022086260-A1 INTERFERON GENE STIMULATOR COMPOSITION COMPRISING INDOLIZINE DERIVATIVE AS ACTIVE INGREDIENT 아주대학교산학협력단 2022-04-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230390319-A1 INTERFERON GENE STIMULATOR COMPOSITION COMPRISING INDOLIZINE DERIVATIVE AS ACTIVE INGREDIENT STING1, IRF3, IFNG BAZ2B 4487/4885BAZ2A 4020/4885ALDH1A1 3672/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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