Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 3/20 | 0.38 |
| ▸ | MMP7 | P09237 | 3/20 | 0.38 |
| ▸ | MMP12 | P39900 | 3/20 | 0.38 |
| ▸ | MMP13 | P45452 | 3/20 | 0.38 |
| ▸ | ACE | P12821 | 2/20 | 0.38 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25524117 | 0.92 | TDP1 (0.53) | TDP1CCR5ESR1NR1I2SMN1; SMN2 | |
| SCHEMBL600070 | 0.75 | ADAMTS5 (0.51) | TDP1CCR5ESR1NR1I2MMP1 | |
| SCHEMBL25520498 | 0.74 | SMN1; SMN2 (0.50) | TDP1CCR5ESR1SMN1; SMN2PSIP1 | |
| SCHEMBL25525118 | 0.74 | CCR5 (0.53) | TDP1CCR5ESR1SMN1; SMN2PSIP1 | |
| SCHEMBL25523725 | 0.73 | TDP1 (0.46) | TDP1CCR5ESR1NR1I2SMN1; SMN2 | |
| SCHEMBL25519385 | 0.73 | TDP1 (0.46) | TDP1CCR5ESR1NR1I2SMN1; SMN2 | |
| SCHEMBL4663012 | 0.71 | TDP1 (0.62) | TDP1CCR5ESR1NR1I2L3MBTL1 | |
| SCHEMBL8356647 | 0.71 | TDP1 (0.62) | TDP1CCR5ESR1NR1I2L3MBTL1 | |
| SCHEMBL4569289 | 0.70 | ADAMTS4 (0.53) | TDP1CCR5ESR1ADAMTS4HSD11B1 | |
| SCHEMBL23054306 | 0.70 | AGER (0.62) | CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159569-A1 | DUAL HDAC6/PROTEASOME INHIBITORS, AND METHODS OF USE THEREOF | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159569-A1 | DUAL HDAC6/PROTEASOME INHIBITORS, AND METHODS OF USE THEREOF | HDAC6, PSMG3, PSMB2 | TDP1 1384/4885CCR5 4784/4885ESR1 4518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.