SCHEMBL255502

SCHEMBL255502

Cc1nc(-c2ccccc2)no1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 4/20 0.74
NR1H4 Q96RI1 3/20 0.63
RAB9A P51151 4/20 0.61
NPC1 O15118 3/20 0.61
NFKB1 P19838 3/20 0.61
NFKB2 Q00653 3/20 0.61
RELA Q04206 3/20 0.61
NOTUM Q6P988 2/20 0.59
CA12 O43570 1/20 0.56
CA1 P00915 1/20 0.56
CA2 P00918 1/20 0.56
CA9 Q16790 1/20 0.56
KDM4E B2RXH2 2/20 0.55
MAPT P10636 2/20 0.55
NPSR1 Q6W5P4 2/20 0.55
HSD17B10 Q99714 2/20 0.55
GAA P10253 1/20 0.55
GPR55 Q9Y2T6 1/20 0.55
PLK1 P53350 1/20 0.54
SMN1; SMN2 Q16637 5/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dimethylamine SCHEMBL7954889 0.94 L3MBTL1 (0.67) L3MBTL1NR1H4RAB9ANPC1NFKB1
SCHEMBL4718445 0.92 L3MBTL1 (0.65) L3MBTL1NR1H4RAB9ANPC1NFKB1
SCHEMBL13415301 0.89 L3MBTL1 (0.69) L3MBTL1NR1H4RAB9ANPC1NFKB1
SCHEMBL6656268 0.86 NR1H4 (0.68) L3MBTL1NR1H4RAB9ANPC1NFKB1
SCHEMBL13130238 0.85 L3MBTL1 (1.00) L3MBTL1RAB9ANPC1CA12CA1
SCHEMBL2967349 0.83 L3MBTL1 (0.62) L3MBTL1NR1H4RAB9ANPC1NFKB1
SCHEMBL13167094 0.81 L3MBTL1 (0.77) L3MBTL1NR1H4RAB9ANPC1NFKB1
SCHEMBL38665653 0.81 L3MBTL1 (0.65) L3MBTL1NR1H4RAB9ANPC1NFKB1
SCHEMBL2655691 0.81 NPC1 (0.62) L3MBTL1RAB9ANPC1NFKB1NFKB2
SCHEMBL2090313 0.80 L3MBTL1 (0.82) L3MBTL1RAB9ANPC1NFKB1NFKB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 306 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070225294-A1 THIAZOLE AND OXAZOLE DERIVATIVES AS ACTIVATORS OF HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS BANKER PIERETTE 2007-09-27 US claimed
US-20060052603-A1 Process for preparing substituted phenoxy-acetic acids from phenols SMITHLKINE BEECHAM CORPORATION 2006-03-09 US claimed
EP-1546124-A1 PROCESS FOR PREPARING SUBSTITUTED PHENOXY-ACETIC ACIDS FROM PHENOLS SmithKline Beecham Corporation (US) 2005-06-29 EP claimed
EP-1349843-B1 THIAZOLE AND OXAZOLE DERIVATIVES AS ACTIVATORS OF HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS SMITHKLINE BEECHAM CORP (US) 2005-04-20 EP claimed
US-20040072838-A1 Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors SMITHKLINE BEECHAM CORPORATION 2004-04-15 US claimed
WO-2004026849-A1 PROCESS FOR PREPARING SUBSTITUTED PHENOXY-ACETIC ACIDS FROM PHENOLS SMITHKLINE BEECHAM CORPORATION (US) 2004-04-01 WO claimed
EP-1349843-A1 THIAZOLE AND OXAZOLE DERIVATIVES AS ACTIVATORS OF HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS GLAXO GROUP LIMITED (GB) 2003-10-08 EP claimed
WO-2002059098-A1 THIAZOLE AND OXAZOLE DERIVATIVES AS ACTIVATORS OF HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS GLAXO GROUP LIMITED (GB) 2002-08-01 WO claimed
US-12336981-B2 Compounds and compositions for the inhibition of NAMPT VALO HEALTH, INC. (US) 2025-06-24 US disclosed
WO-2024137813-A1 MODULATORS OF MITOCHONDRIAL DNA REPLICATION PRETZEL THERAPEUTICS, INC. (US) 2024-06-27 WO disclosed
EP-4328232-A1 ELECTROCHEMICAL BIOSENSOR, OR SENSING MEMBRANE FOR ELECTROCHEMICAL BIOSENSOR CONTAINING TRANSITION METAL COMPLEX OR OXIDATION-REDUCTION POLYMER I-SENS, INC. (KR) 2024-02-28 EP disclosed
US-20230346753-A1 NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT VALO HEALTH, INC. 2023-11-02 US disclosed
US-20230321091-A1 SUBSTITUTED PYRIDAZINONES FOR USE IN THE TREATMENT OF NEUROMUSCULAR DISEASES EDGEWISE THERAPEUTICS, INC. 2023-10-12 US disclosed
US-20230321091-A1 SUBSTITUTED PYRIDAZINONES FOR USE IN THE TREATMENT OF NEUROMUSCULAR DISEASES EDGEWISE THERAPEUTICS, INC. 2023-10-12 US disclosed
WO-2004002491-A1 MORPHOLINE AND TETRAHYDROPYRAN DRIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS AVENTIS PHARMACEUTICALS INC. (US) 2004-01-08 WO disclosed
EP-1349843-A1 THIAZOLE AND OXAZOLE DERIVATIVES AS ACTIVATORS OF HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS GLAXO GROUP LIMITED (GB) 2003-10-08 EP disclosed
WO-2002059098-A1 THIAZOLE AND OXAZOLE DERIVATIVES AS ACTIVATORS OF HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS GLAXO GROUP LIMITED (GB) 2002-08-01 WO disclosed
EP-0123378-B1 1-NORMONYL DERIVATIVES, PROCESSES AND USE BEECHAM GROUP PLC (GB) 1989-09-06 EP disclosed
US-4861788-A FUNGICIDE, BACTERICIDE BEECHAM GROUP PLC (GB) 1989-08-29 US disclosed
EP-0123378-A2 1-Normonyl derivatives, processes and use BEECHAM GROUP PLC (GB) 1984-10-31 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230321091-A1 SUBSTITUTED PYRIDAZINONES FOR USE IN THE TREATMENT OF NEUROMUSCULAR DISEASES IL6, MUSK, SMN1; SMN2 L3MBTL1 3930/4885NR1H4 4814/4885RAB9A 2744/4885
US-12336981-B2 Compounds and compositions for the inhibition of NAMPT NAMPT, NNMT, NNT L3MBTL1 3102/4885NR1H4 932/4885RAB9A 1657/4885
US-20070225294-A1 THIAZOLE AND OXAZOLE DERIVATIVES AS ACTIVATORS OF HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS GPR119, PPARA, PPARG L3MBTL1 2460/4885NR1H4 55/4885RAB9A 4362/4885
US-20060052603-A1 Process for preparing substituted phenoxy-acetic acids from phenols HPD, PAH, GNPAT L3MBTL1 4879/4885NR1H4 706/4885RAB9A 1724/4885
US-20040072838-A1 Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors PPARA, PPARG, PPARD L3MBTL1 3527/4885NR1H4 18/4885RAB9A 3271/4885
US-20230346753-A1 NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT NAMPT, NNMT, NQO1 L3MBTL1 3563/4885NR1H4 666/4885RAB9A 1445/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.