Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 8/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 8/20 | 0.46 |
| ▸ | GSK3A | P49840 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | STK3 | Q13188 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24910166 | 0.87 | SLC40A1 (0.44) | NCF1PARP1NR1H2NR1H3PSMD14 | |
| SCHEMBL5548572 | 0.81 | NCF1 (0.45) | NCF1PARP1NR1H2NR1H3GSK3A | |
| SCHEMBL12128843 | 0.80 | LMNA (0.45) | PSMD14COPS5TNFCYP3A4CYP2C19 | |
| SCHEMBL21173367 | 0.79 | PARP1 (0.41) | PARP1GSK3AGSK3BPRKD3MAP4K4 | |
| SCHEMBL9033424 | 0.77 | PSMD14 (0.62) | NCF1PARP1NR1H2NR1H3GSK3A | |
| SCHEMBL12131703 | 0.77 | HTR1A (0.53) | PARP1PSMD14COPS5MEN1KMT2A | |
| SCHEMBL16248304 | 0.77 | NCF1 (0.52) | NCF1PARP1NR1H2NR1H3GSK3A | |
| SCHEMBL13409380 | 0.76 | NCF1 (0.46) | NCF1PARP1NR1H2NR1H3GSK3A | |
| SCHEMBL2876591 | 0.76 | NCF1 (0.51) | NCF1PARP1NR1H2NR1H3GSK3A | |
| SCHEMBL317787 | 0.76 | NCF1 (0.51) | NCF1PARP1NR1H2NR1H3GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230181546-A1 | TREATMENT OF RESPIRATORY DISEASES WITH AMINO ACID COMPOUNDS | PLIANT THERAPEUTICS INC (US) | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230181546-A1 | TREATMENT OF RESPIRATORY DISEASES WITH AMINO ACID COMPOUNDS | ITGA5, ITGAL, ITGB5 | NCF1 1663/4885PARP1 2338/4885NR1H2 881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.