Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.38 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15651278 | 0.83 | KDM4E (0.41) | L3MBTL1SLC9A1SLC9A2ANPEPALDH1A1 | |
| SCHEMBL157770 | 0.81 | RAPGEF4 (0.47) | L3MBTL1SLC9A1SLC9A2ANPEPALDH1A1 | |
| SCHEMBL1929488 | 0.79 | TRPV4 (0.44) | SLC9A1SLC9A2TRPV4ALDH1A1TSHR | |
| SCHEMBL25754886 | 0.79 | LMNA (0.47) | SLC9A1SLC9A2TRPV4ALDH1A1HPGD | |
| SCHEMBL25759568 | 0.75 | SLC9A1 (0.39) | SLC9A1SLC9A2TRPV4ALDH1A1HPGD | |
| SCHEMBL8493031 | 0.75 | L3MBTL1 (0.52) | L3MBTL1TRPV4ALDH1A1CYP3A4TSHR | |
| SCHEMBL7027875 | 0.74 | TRPV4 (0.37) | L3MBTL1SLC9A1TRPV4ALDH1A1MEN1 | |
| SCHEMBL30534761 | 0.74 | TRPV4 (0.37) | L3MBTL1SLC9A1TRPV4ALDH1A1MEN1 | |
| SCHEMBL31587739 | 0.74 | ACE2 (0.50) | SLC9A1SLC9A2TSHRHSD17B10TDP1 | |
| SCHEMBL3971731 | 0.74 | ACE2 (0.50) | SLC9A1SLC9A2TSHRHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230174523-A1 | BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | AMATHUS THERAPEUTICS, INC. (US) | 2023-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230174523-A1 | BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | TRAP1, PINK1, TP53BP1 | L3MBTL1 2375/4885SLC9A1 1050/4885SLC9A2 2907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.