Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2579648 | 0.96 | HTR3E (0.48) | GAAHTR3EHTR3BADRB1HTR3A | |
| Thiourea SCHEMBL2584115 | 0.87 | POLB (0.49) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL16789887 | 0.79 | HTR3E (0.52) | GAAHTR3EHTR3BADRB1HTR3A | |
| Trifluoromethanesulfonic Acid SCHEMBL2584928 | 0.78 | NOX4 (0.50) | GAARAB9ACA12CA1CA2 | |
| SCHEMBL11178945 | 0.76 | SIGMAR1 (0.54) | GAAHTR3EHTR3BADRB1HTR3A | |
| SCHEMBL16786533 | 0.73 | ACHE (0.58) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL2884739 | 0.70 | HTR3E (0.51) | GAAHTR3EHTR3BADRB1HTR3A | |
| SCHEMBL12427204 | 0.70 | NOX4 (0.49) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL28599511 | 0.70 | HTR3E (0.73) | GAAHTR3EHTR3BADRB1HTR3A | |
| SCHEMBL29656856 | 0.70 | HTR3E (0.73) | GAAHTR3EHTR3BADRB1HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8722897-B2 | Metal complexes of thiourea and derivatives as metal delivering anti-cancer and anti-inflammatory agents | GOLDPORP PHARMA LIMITED (CN) | 2014-05-13 | — | — | US | claimed |
| US-20110269730-A1 | Metal Complexes of Thiourea and Derivatives as Metal Delivering Anti-Cancer and Anti-Inflammatory Agents | GOLDPORP PHARMA LIMITED (CN) | 2011-11-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269730-A1 | Metal Complexes of Thiourea and Derivatives as Metal Delivering Anti-Cancer and Anti-Inflammatory Agents | CLIC1, SLC30A5, TIA1 | GAA 2482/4885HTR3E 3637/4885HTR3B 4099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.