Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trifluoromethanesulfonic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PKLR | P30613 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2579648 | 0.82 | HTR3E (0.48) | SMN1; SMN2NPC1PKMRAB9ACA1 | |
| Hydrochloric Acid SCHEMBL2579274 | 0.78 | GAA (0.46) | SMN1; SMN2NPC1PKMRAB9ACA1 | |
| Thiourea SCHEMBL2584115 | 0.74 | POLB (0.49) | LMNASMN1; SMN2 | |
| Trifluoromethanesulfonic Acid SCHEMBL8373803 | 0.70 | KCNH2 (0.45) | NPC1PKMPKLRRAB9ACA1 | |
| Trifluoromethanesulfonic Acid SCHEMBL454992 | 0.69 | PKM (0.47) | NPC1PKMPKLRRAB9ACA1 | |
| Trifluoromethanesulfonic Acid SCHEMBL5828338 | 0.69 | PKM (0.47) | NPC1PKMPKLRRAB9ACA1 | |
| Trifluoromethanesulfonic Acid SCHEMBL1592826 | 0.69 | PKM (0.47) | NPC1PKMPKLRRAB9ACA1 | |
| Trifluoromethanesulfonic Acid SCHEMBL5146818 | 0.68 | KCNH2 (0.46) | NPC1PKMPKLRRAB9ACA1 | |
| SCHEMBL16789887 | 0.68 | HTR3E (0.52) | LMNATSHRSMN1; SMN2NPC1PKM | |
| SCHEMBL20681675 | 0.67 | NOX4 (1.00) | NOX4LMNATSHRSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8722897-B2 | Metal complexes of thiourea and derivatives as metal delivering anti-cancer and anti-inflammatory agents | GOLDPORP PHARMA LIMITED (CN) | 2014-05-13 | — | — | US | claimed |
| US-20110269730-A1 | Metal Complexes of Thiourea and Derivatives as Metal Delivering Anti-Cancer and Anti-Inflammatory Agents | GOLDPORP PHARMA LIMITED (CN) | 2011-11-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269730-A1 | Metal Complexes of Thiourea and Derivatives as Metal Delivering Anti-Cancer and Anti-Inflammatory Agents | CLIC1, SLC30A5, TIA1 | NOX4 1963/4885LMNA 4644/4885TSHR 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.