Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 13/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 4/20 | 0.32 |
| ▸ | FLT3 | P36888 | 3/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.30 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2581492 | 0.90 | KCNH2 (0.34) | KCNH2GRIN2BMETJAK2FLT3 | |
| SCHEMBL2571385 | 0.86 | PTGDR2 (0.41) | KCNH2GRIN2BMETJAK2FLT3 | |
| SCHEMBL2580577 | 0.84 | TGFBR1 (0.30) | — | |
| SCHEMBL2573868 | 0.83 | PTGDR2 (0.33) | KCNH2GRIN2BMETJAK2FLT3 | |
| SCHEMBL2579246 | 0.82 | PTGDR2 (0.34) | — | |
| SCHEMBL533987 | 0.79 | AR (0.36) | — | |
| SCHEMBL2580083 | 0.77 | GPR4 (0.32) | GRIN2B | |
| SCHEMBL2575500 | 0.75 | KCNH2 (0.36) | KCNH2 | |
| SCHEMBL2582687 | 0.75 | ROCK2 (0.35) | KCNH2GRIN2B | |
| SCHEMBL2580572 | 0.75 | TGFBR1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139881-B1 | QUINOLINES AND THEIR THERAPEUTIC USE | PULMAGEN THERAPEUTICS ASTHMA LTD (GB) | 2011-11-09 | — | — | EP | claimed |
| EP-2139881-A1 | QUINOLINES AND THEIR THERAPEUTIC USE | Argenta Oral Therapeutics Limited (GB) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008122784-A1 | QUINOLINES AND THEIR THERAPEUTIC USE | ARGENTA DISCOVERY LIMITED (GB) | 2008-10-16 | — | — | WO | disclosed |