Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 3/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | TACR3 | P29371 | 1/20 | 0.41 |
| ▸ | PTGFR | P43088 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14923033 | 0.87 | KDM4E (0.64) | KDM4EALDH1A1L3MBTL1ADORA3NR1I2 | |
| SCHEMBL19840411 | 0.85 | KMT2A (0.51) | KDM4EALDH1A1L3MBTL1ADORA3NR1I2 | |
| SCHEMBL19840414 | 0.82 | KMT2A (0.48) | KDM4EALDH1A1L3MBTL1ADORA3NR1I2 | |
| SCHEMBL14923034 | 0.77 | KMT2A (0.55) | KDM4EALDH1A1L3MBTL1ADORA3NR1I2 | |
| SCHEMBL24702677 | 0.75 | MEN1 (0.55) | L3MBTL1ADORA3NR1I2EGFRADRA2A | |
| SCHEMBL13585400 | 0.74 | WHR1 (0.56) | KDM4EALDH1A1L3MBTL1ADORA3MAPT | |
| SCHEMBL18456158 | 0.73 | WHR1 (0.59) | KDM4EALDH1A1L3MBTL1ADORA3NR1I2 | |
| SCHEMBL12587959 | 0.73 | ALDH1A1 (0.47) | KDM4EALDH1A1L3MBTL1MAPTLMNA | |
| SCHEMBL1102420 | 0.72 | KDM4E (0.61) | KDM4EALDH1A1L3MBTL1MAPTLMNA | |
| SCHEMBL2757113 | 0.72 | LMNA (0.39) | KDM4EALDH1A1MAPTLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11697804-B2 | Transcriptionally targeted and CpG-free plasmid for theranostic gene therapy | THE JOHNS HOPKINS UNIVERSITY (US) | 2023-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11697804-B2 | Transcriptionally targeted and CpG-free plasmid for theranostic gene therapy | POLRMT, HDGF, PCNP | KDM4E 3337/4885ALDH1A1 3433/4885L3MBTL1 109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.