Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 3/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 4/20 | 0.32 |
| ▸ | KIT | P10721 | 2/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14626209 | 0.86 | KIF11 (0.47) | NPC1HPGDRAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL3359576 | 0.86 | KIF11 (0.47) | NPC1RAB9ASMN1; SMN2KIF11ADORA3 | |
| Hydrochloric Acid SCHEMBL20502848 | 0.85 | KIF11 (0.46) | NPC1RAB9ASMN1; SMN2KIF11ADORA3 | |
| SCHEMBL16311077 | 0.80 | ADORA3 (0.40) | NPC1HPGDRAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL27435402 | 0.75 | NPC1 (0.37) | NPC1HPGDRAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL2666085 | 0.74 | TSHR (0.37) | HPGDSMN1; SMN2CYP1A2TSHRALDH1A1 | |
| SCHEMBL17973952 | 0.72 | MAPT (0.42) | TSHRALDH1A1MAPTRECQLTP53 | |
| SCHEMBL2708355 | 0.69 | ALOX5 (0.35) | TSHRMAPTTP53 | |
| SCHEMBL4547924 | 0.69 | LMNA (0.35) | HPGDTSHRALDH1A1PDK2HSD17B10 | |
| SCHEMBL25505996 | 0.69 | ALOX15 (0.40) | NPC1HPGDRAB9ASMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230227438-A1 | AZASPIROCYCLES AS MONOACYLGLYCEROL LIPASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2023-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230227438-A1 | AZASPIROCYCLES AS MONOACYLGLYCEROL LIPASE MODULATORS | MGLL, LPAR1, LPL | NPC1 884/4885HPGD 1695/4885RAB9A 1800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.