Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 2/20 | 0.40 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
| ▸ | LPAR3 | Q9UBY5 | 7/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 4/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.36 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11516009 | 0.85 | TDP1 (0.42) | ALDH1A1LMNAPRKCAPRKCEPRKCQ | |
| SCHEMBL3677069 | 0.81 | TDP1 (0.33) | — | |
| SCHEMBL11686114 | 0.77 | FAAH (0.39) | ALDH1A1LMNAPRKCA | |
| SCHEMBL10877359 | 0.77 | — | — | |
| SCHEMBL3675625 | 0.76 | TDP1 (0.38) | — | |
| SCHEMBL3681070 | 0.76 | TDP1 (0.42) | — | |
| SCHEMBL2887233 | 0.74 | TSHR (0.48) | ALDH1A1LMNA | |
| SCHEMBL142561 | 0.73 | — | — | |
| SCHEMBL29517095 | 0.73 | ALDH1A1 (0.47) | ALDH1A1LMNAPRKCAPRKCEPRKCQ | |
| SCHEMBL5308587 | 0.71 | ALDH1A1 (0.55) | ALDH1A1LMNAPRKCAPRKCEPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10351537-B2 | Processes for the preparation of lesinurad and intermediates thereof | APOTEX INC. (CA) | 2019-07-16 | — | — | US | disclosed |
| US-10351537-B2 | Processes for the preparation of lesinurad and intermediates thereof | APOTEX INC. (CA) | 2019-07-16 | — | — | US | disclosed |
| US-20180258057-A1 | Processes for the Preparation of Lesinurad and Intermediates Thereof | THE BANK OF NOVA SCOTIA (CA) | 2018-09-13 | — | — | US | disclosed |
| EP-2013240-B1 | PROCESS FOR THE PREPARATION OF CROSSLINKED NITROXIDE POLYMERS | PIOTREK CO LTD (JP) | 2017-05-31 | — | — | EP | disclosed |
| US-9512275-B2 | Low viscosity polyorganosiloxanes comprising quaternary ammonium groups, methods for the production and the use thereof (II) | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2016-12-06 | — | — | US | disclosed |
| US-20160023998-A1 | HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS | BEZWADA BIOMEDICAL LLC (US) | 2016-01-28 | — | — | US | disclosed |
| US-20160023998-A1 | HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS | BEZWADA BIOMEDICAL LLC (US) | 2016-01-28 | — | — | US | disclosed |
| US-20160023998-A1 | HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS | BEZWADA BIOMEDICAL LLC (US) | 2016-01-28 | — | — | US | disclosed |
| US-9174924-B2 | Hydrolysable linkers and cross-linkers for absorbable polymers | BEZWADA BIOMEDICAL, LLC (US) | 2015-11-03 | — | — | US | disclosed |
| US-9174924-B2 | Hydrolysable linkers and cross-linkers for absorbable polymers | BEZWADA BIOMEDICAL, LLC (US) | 2015-11-03 | — | — | US | disclosed |
| US-20090292029-A1 | BIOABSORBABLE POLYMERS FROM BIOABSORBABLE POLYISOCYANATES AND USES THEREOF | BEZWADA BIOMEDICAL, L.L.C (US) | 2009-11-26 | — | — | US | disclosed |
| US-20090292029-A1 | BIOABSORBABLE POLYMERS FROM BIOABSORBABLE POLYISOCYANATES AND USES THEREOF | BEZWADA BIOMEDICAL, L.L.C (US) | 2009-11-26 | — | — | US | disclosed |
| US-20090082540-A1 | HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS | BEZWADA BIOMEDICAL, LLC (US) | 2009-03-26 | — | — | US | disclosed |
| US-20090082540-A1 | HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS | BEZWADA BIOMEDICAL, LLC (US) | 2009-03-26 | — | — | US | disclosed |
| US-20090082540-A1 | HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS | BEZWADA BIOMEDICAL, LLC (US) | 2009-03-26 | — | — | US | disclosed |
| EP-2013240-A1 | PROCESS FOR THE PREPARATION OF CROSSLINKED NITROXIDE POLYMERS | PIOTREK CO., LTD. (JP) | 2009-01-14 | — | — | EP | disclosed |
| US-7390479-B2 | Branched polyorganosiloxane polymers | GE BAYER SILICONES GMBH & CO. KG (DE) | 2008-06-24 | — | — | US | disclosed |
| WO-2007115939-A1 | PROCESS FOR THE PREPARATION OF CROSSLINKED NITROXIDE POLYMERS | PIOTREK CO., LTD. (JP) | 2007-10-18 | — | — | WO | disclosed |
| US-3971757-A | STABILIZERS FOR POLYMERS | CIBA-GEIGY CORPORATION (US) | 1976-07-27 | — | — | US | disclosed |
| US-3966711-A | 4-Alkyl-1,4-diaza-5-oxo-cycloheptanes and their 1-oxyls | CIBA-GEIGY CORPORATION (US) | 1976-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180258057-A1 | Processes for the Preparation of Lesinurad and Intermediates Thereof | LSS, SQOR, PGD | ALDH1A1 155/4885LMNA 252/4885PRKCA 3405/4885 |
| US-20090082540-A1 | HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS | SI, KDM8, APEH | ALDH1A1 1051/4885LMNA 2710/4885PRKCA 3448/4885 |
| US-20160023998-A1 | HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS | SI, KDM8, APEH | ALDH1A1 1051/4885LMNA 2710/4885PRKCA 3448/4885 |
| US-10351537-B2 | Processes for the preparation of lesinurad and intermediates thereof | LSS, SQOR, PGD | ALDH1A1 155/4885LMNA 252/4885PRKCA 3405/4885 |
| US-20090292029-A1 | BIOABSORBABLE POLYMERS FROM BIOABSORBABLE POLYISOCYANATES AND USES THEREOF | PUF60, PFAS, UROD | ALDH1A1 2465/4885LMNA 2784/4885PRKCA 1660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.