Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 3/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.49 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2578691 | 0.92 | WNT1 (0.53) | WNT1DYRK1ANPC1TSHRMAPK1 | |
| SCHEMBL2585927 | 0.77 | WNT1 (0.46) | WNT1DYRK1ANAMPTMAPK1SMN1; SMN2 | |
| SCHEMBL2576273 | 0.77 | ALDH1A1 (0.48) | NPC1TSHRMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL2589092 | 0.76 | HIF1A (0.43) | DYRK1ANAMPTHDAC4HDAC6 | |
| SCHEMBL2589522 | 0.74 | EPHX2 (0.56) | NPC1TSHRRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2590019 | 0.74 | HIF1A (0.68) | WNT1DYRK1ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2582356 | 0.74 | KMT2A (0.46) | DYRK1ANAMPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2585532 | 0.73 | HIF1A (0.52) | DYRK1ANPC1TSHRMAPK1RAB9A | |
| SCHEMBL15477410 | 0.71 | SMN1; SMN2 (0.66) | NPC1TSHRRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL31086753 | 0.70 | KDM4E (0.55) | NPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |