Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PRKCG | P05129 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | PRKX | P51817 | 1/20 | 0.48 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2585707 | 0.88 | RAB9A (0.54) | HIF1AKMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2589522 | 0.85 | EPHX2 (0.56) | HIF1AKMT2ASMN1; SMN2RAB9AHPGD | |
| SCHEMBL2581683 | 0.81 | ECE1 (0.48) | HIF1AKMT2ASMN1; SMN2RAB9AROCK2 | |
| SCHEMBL2586922 | 0.80 | HIF1A (0.72) | HIF1ALMNARAB9ANPC1ROCK1 | |
| SCHEMBL2584587 | 0.79 | ROCK2 (0.48) | HIF1AKMT2ASMN1; SMN2GAAROCK2 | |
| SCHEMBL2582356 | 0.78 | KMT2A (0.46) | HIF1AKMT2ALMNASMN1; SMN2RAB9A | |
| SCHEMBL2585139 | 0.78 | LMNA (0.58) | KMT2ALMNASMN1; SMN2HPGDGAA | |
| SCHEMBL2589092 | 0.77 | HIF1A (0.43) | HIF1AROCK2GSK3BDYRK1A | |
| SCHEMBL2582407 | 0.76 | P2RX7 (0.54) | HIF1AROCK2CYP1A2CYP2C19TP53 | |
| SCHEMBL2587088 | 0.76 | GSK3B (0.46) | HIF1AKMT2AROCK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |