Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.40 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.40 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2576273 | 0.82 | ALDH1A1 (0.48) | HIF1AMAPK1HDAC4HDAC6KDM4E | |
| SCHEMBL2582356 | 0.80 | KMT2A (0.46) | DYRK1AHIF1ANAMPTHDAC4ALDH1A1 | |
| SCHEMBL2585707 | 0.79 | RAB9A (0.54) | HIF1AMAPK1CYP1A2ALDH1A1HSD17B10 | |
| SCHEMBL2586722 | 0.77 | WNT1 (0.49) | WNT1DYRK1ANAMPTMAPK1HDAC4 | |
| SCHEMBL2589522 | 0.77 | EPHX2 (0.56) | HIF1AKDM4EALDH1A1HSD17B10HTT | |
| SCHEMBL2585532 | 0.76 | HIF1A (0.52) | DYRK1AHIF1AMAPK1CYP1A2ALDH1A1 | |
| SCHEMBL2589092 | 0.76 | HIF1A (0.43) | DYRK1AHIF1ANAMPTHDAC4HDAC6 | |
| SCHEMBL2582407 | 0.75 | P2RX7 (0.54) | HIF1ACYP1A2 | |
| SCHEMBL2576123 | 0.72 | TSHR (0.46) | HIF1AMAPK1KDM4EALDH1A1HTT | |
| SCHEMBL2590019 | 0.72 | HIF1A (0.68) | WNT1DYRK1AHIF1AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |