Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.43 |
| ▸ | CNR1 | P21554 | 3/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2582356 | 0.78 | KMT2A (0.46) | HIF1ANAMPTGSK3BKDM4CDYRK1A | |
| SCHEMBL2590019 | 0.78 | HIF1A (0.68) | HIF1ADYRK1A | |
| SCHEMBL2585532 | 0.77 | HIF1A (0.52) | HIF1AGSK3BDYRK1AROCK2 | |
| SCHEMBL2576273 | 0.76 | ALDH1A1 (0.48) | HIF1AHDAC4HDAC6 | |
| SCHEMBL2585927 | 0.76 | WNT1 (0.46) | HIF1ANAMPTDYRK1AHDAC4HDAC6 | |
| SCHEMBL3524477 | 0.76 | SCD5 (0.47) | HIF1AGSK3BMLLT1HDAC4HDAC6 | |
| SCHEMBL2586722 | 0.76 | WNT1 (0.49) | NAMPTDYRK1AHDAC4HDAC6 | |
| SCHEMBL2585707 | 0.75 | RAB9A (0.54) | HIF1A | |
| SCHEMBL2589522 | 0.73 | EPHX2 (0.56) | HIF1AKDM4CROCK2 | |
| SCHEMBL2586922 | 0.72 | HIF1A (0.72) | HIF1ANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |