Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2585927 | 0.82 | WNT1 (0.46) | ALDH1A1HDAC4HDAC6HIF1AKDM4E | |
| SCHEMBL2589522 | 0.82 | EPHX2 (0.56) | ALDH1A1TSHRL3MBTL1HIF1ANPC1 | |
| SCHEMBL2582356 | 0.80 | KMT2A (0.46) | ALDH1A1GAAHDAC4HIF1ANPC1 | |
| SCHEMBL2585707 | 0.79 | RAB9A (0.54) | ALDH1A1TRPV1GAAL3MBTL1HIF1A | |
| SCHEMBL2586722 | 0.77 | WNT1 (0.49) | ALDH1A1HDAC4HDAC6TSHRNPC1 | |
| SCHEMBL2305838 | 0.76 | HIF1A (0.57) | ALDH1A1HIF1ARAB9AKDM4EHPGD | |
| SCHEMBL2578691 | 0.76 | WNT1 (0.53) | ALDH1A1TSHRNPC1RAB9AKMT2A | |
| SCHEMBL2585532 | 0.76 | HIF1A (0.52) | ALDH1A1GAATP53TSHRHIF1A | |
| SCHEMBL2589092 | 0.76 | HIF1A (0.43) | HDAC4HDAC6HIF1A | |
| SCHEMBL2582407 | 0.75 | P2RX7 (0.54) | TP53HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |