Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | BAD | Q92934 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2576123 | 0.81 | TSHR (0.46) | KMT2AMEN1HIF1ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2576273 | 0.80 | ALDH1A1 (0.48) | KMT2AMEN1HIF1ARAB9AHPGD | |
| SCHEMBL2585927 | 0.80 | WNT1 (0.46) | DYRK1AHIF1ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL2585532 | 0.78 | HIF1A (0.52) | KMT2ADYRK1AHIF1ARAB9AHPGD | |
| SCHEMBL2589092 | 0.78 | HIF1A (0.43) | DYRK1AHIF1ANAMPTKDM4CHDAC4 | |
| SCHEMBL2585707 | 0.76 | RAB9A (0.54) | KMT2AMEN1HIF1ARAB9ANPC1 | |
| SCHEMBL2586722 | 0.74 | WNT1 (0.49) | DYRK1ARAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2589522 | 0.74 | EPHX2 (0.56) | KMT2AMEN1HIF1ARAB9AHPGD | |
| SCHEMBL2585139 | 0.74 | LMNA (0.58) | KMT2AMEN1HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL2581794 | 0.74 | HIF1A (0.60) | HIF1ARAB9AHPGDNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |